Children with sickle cell disease and severe COVID‐19 presenting single nucleotide polymorphisms in innate immune response genes – A case report

Here we report three clinical cases of children with sickle cell disease (SCD) and severe COVID‐19 who evolved with complications during hospitalization or after discharge. They present single nucleotide polymorphisms in tlr‐7 and tirap genes, identified from 37 patients under 16 years old hospitali...

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Bibliographic Details
Published in:EJHaem 2022-02, Vol.3 (1), p.199-202
Main Authors: Pessoa, Natália Lima, Diniz, Lilian Martins Oliveira, Andrade, Adriana de Souza, Kroon, Erna Geessien, Bentes, Aline Almeida, Campos, Marco Antônio
Format: Article
Language:English
Subjects:
Adapter proteins
Antigens
Blood
Case Report
Case Reports
Children
Coronaviruses
COVID-19
Erythrocytes
Fever
Genes
Hemoglobin
Hospitalization
Hospitals
Immune response
Immune system
Innate immunity
Morphine
Oxygen saturation
Oxygen therapy
Pain
Patients
Pattern recognition
Severe acute respiratory syndrome coronavirus 2
Sickle cell disease
single nucleotide polymorphisms
Single-nucleotide polymorphism
Spleen
TIRAP
TLR‐7
Tomography
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Summary:Here we report three clinical cases of children with sickle cell disease (SCD) and severe COVID‐19 who evolved with complications during hospitalization or after discharge. They present single nucleotide polymorphisms in tlr‐7 and tirap genes, identified from 37 patients under 16 years old hospitalized from September 2020 to May 2021 in the Hospital João Paulo II, Belo Horizonte, Brazil. They presented significant complications of SCD as acute chest syndrome, splenic sequestration, and pain crisis during hospitalization or up to 2 months after SARS‐CoV‐2 infection. They all required transfusion of concentrated red blood cells and hospitalization in a reference hospital to care for children with SCD.
ISSN:2688-6146
2688-6146
DOI:10.1002/jha2.325