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Host insulin resistance caused by Porphyromonas gingivalis -review of recent progresses
is a Gram-negative oral anaerobic bacterium that plays a key role in the pathogenesis of periodontitis. expresses a variety of virulence factors that disrupt innate and adaptive immunity, allowing to survive and multiply in the host and destroy periodontal tissue. In addition to periodontal disease,...
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| Published in: | Frontiers in cellular and infection microbiology 2023-07, Vol.13, p.1209381 |
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| Language: | English |
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| container_start_page | 1209381 |
| container_title | Frontiers in cellular and infection microbiology |
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| creator | Jia, Shuxian Li, Xiaobing Du, Qin |
| description | is a Gram-negative oral anaerobic bacterium that plays a key role in the pathogenesis of periodontitis.
expresses a variety of virulence factors that disrupt innate and adaptive immunity, allowing
to survive and multiply in the host and destroy periodontal tissue. In addition to periodontal disease,
is also associated with systemic diseases, of which insulin resistance is an important pathological basis.
causes a systemic inflammatory response, disrupts insulin signaling pathways, induces pancreatic β-cell hypofunction and reduced numbers, and causes decreased insulin sensitivity leading to insulin resistance (IR). In this paper, we systematically review the studies on the mechanism of insulin resistance induced by
, discuss the association between
and systemic diseases based on insulin resistance, and finally propose relevant therapeutic approaches. Overall, through a systematic review of the mechanisms related to systemic diseases caused by
through insulin resistance, we hope to provide new insights for future basic research and clinical interventions for related systemic diseases. |
| doi_str_mv | 10.3389/fcimb.2023.1209381 |
| format | article |
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expresses a variety of virulence factors that disrupt innate and adaptive immunity, allowing
to survive and multiply in the host and destroy periodontal tissue. In addition to periodontal disease,
is also associated with systemic diseases, of which insulin resistance is an important pathological basis.
causes a systemic inflammatory response, disrupts insulin signaling pathways, induces pancreatic β-cell hypofunction and reduced numbers, and causes decreased insulin sensitivity leading to insulin resistance (IR). In this paper, we systematically review the studies on the mechanism of insulin resistance induced by
, discuss the association between
and systemic diseases based on insulin resistance, and finally propose relevant therapeutic approaches. Overall, through a systematic review of the mechanisms related to systemic diseases caused by
through insulin resistance, we hope to provide new insights for future basic research and clinical interventions for related systemic diseases.</description><identifier>ISSN: 2235-2988</identifier><identifier>EISSN: 2235-2988</identifier><identifier>DOI: 10.3389/fcimb.2023.1209381</identifier><identifier>PMID: 37520442</identifier><language>eng</language><publisher>Switzerland: Frontiers Media S.A</publisher><subject>Alzheimer’s disease ; Base Composition ; Cellular and Infection Microbiology ; diabetes ; FFA ; Humans ; Insulin ; Insulin Resistance ; Phylogeny ; Porphyromonas gingivalis ; RNA, Ribosomal, 16S ; Sequence Analysis, DNA</subject><ispartof>Frontiers in cellular and infection microbiology, 2023-07, Vol.13, p.1209381</ispartof><rights>Copyright © 2023 Jia, Li and Du.</rights><rights>Copyright © 2023 Jia, Li and Du 2023 Jia, Li and Du</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-92eda60dd727b95176f382d2e2096aba0e6251842ed04457f94955e24291dcc93</citedby><cites>FETCH-LOGICAL-c469t-92eda60dd727b95176f382d2e2096aba0e6251842ed04457f94955e24291dcc93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373507/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373507/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27915,27916,53782,53784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37520442$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jia, Shuxian</creatorcontrib><creatorcontrib>Li, Xiaobing</creatorcontrib><creatorcontrib>Du, Qin</creatorcontrib><title>Host insulin resistance caused by Porphyromonas gingivalis -review of recent progresses</title><title>Frontiers in cellular and infection microbiology</title><addtitle>Front Cell Infect Microbiol</addtitle><description>is a Gram-negative oral anaerobic bacterium that plays a key role in the pathogenesis of periodontitis.
expresses a variety of virulence factors that disrupt innate and adaptive immunity, allowing
to survive and multiply in the host and destroy periodontal tissue. In addition to periodontal disease,
is also associated with systemic diseases, of which insulin resistance is an important pathological basis.
causes a systemic inflammatory response, disrupts insulin signaling pathways, induces pancreatic β-cell hypofunction and reduced numbers, and causes decreased insulin sensitivity leading to insulin resistance (IR). In this paper, we systematically review the studies on the mechanism of insulin resistance induced by
, discuss the association between
and systemic diseases based on insulin resistance, and finally propose relevant therapeutic approaches. Overall, through a systematic review of the mechanisms related to systemic diseases caused by
through insulin resistance, we hope to provide new insights for future basic research and clinical interventions for related systemic diseases.</description><subject>Alzheimer’s disease</subject><subject>Base Composition</subject><subject>Cellular and Infection Microbiology</subject><subject>diabetes</subject><subject>FFA</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Phylogeny</subject><subject>Porphyromonas gingivalis</subject><subject>RNA, Ribosomal, 16S</subject><subject>Sequence Analysis, DNA</subject><issn>2235-2988</issn><issn>2235-2988</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkUtv1DAUhS0EolXpH2CBsmSTwbl-rxCqgFaqBAsQS8vxI3WVxIOdTDX_Hk9nqFov7Cv7ns_n6iD0vsMbQqT6FGyc-g1gIJsOsCKye4XOAQhrQUn5-ll9hi5Lucd1CQxSkbfojAgGmFI4R3-uU1maOJd1jHOTfYllMbP1jTVr8a7p983PlLd3-5ymNJvSDHEe4s6MsTRt9rvoH5oUqtD6eWm2OQ2VUXx5h94EMxZ_eTov0O9vX39dXbe3P77fXH25bS3lamkVeGc4dk6A6BXrBA9EggNfR-KmN9hzYJ2kta36ZSIoqhjzQEF1zlpFLtDNkeuSudfbHCeT9zqZqB8vUh60yUu0o9cQAuWdDb3qFWWs7gZLAVy6UC3wvrI-H1nbtZ-8O0yUzfgC-vJljnd6SDvdYSIIw6ISPp4IOf1dfVn0FIv142hmn9aiQVKKJQd6aIVjq82plOzD0z8d1oeE9WPC-pCwPiVcRR-eO3yS_M-T_ANDWaPJ</recordid><startdate>20230713</startdate><enddate>20230713</enddate><creator>Jia, Shuxian</creator><creator>Li, Xiaobing</creator><creator>Du, Qin</creator><general>Frontiers Media S.A</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20230713</creationdate><title>Host insulin resistance caused by Porphyromonas gingivalis -review of recent progresses</title><author>Jia, Shuxian ; Li, Xiaobing ; Du, Qin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-92eda60dd727b95176f382d2e2096aba0e6251842ed04457f94955e24291dcc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alzheimer’s disease</topic><topic>Base Composition</topic><topic>Cellular and Infection Microbiology</topic><topic>diabetes</topic><topic>FFA</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin Resistance</topic><topic>Phylogeny</topic><topic>Porphyromonas gingivalis</topic><topic>RNA, Ribosomal, 16S</topic><topic>Sequence Analysis, DNA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jia, Shuxian</creatorcontrib><creatorcontrib>Li, Xiaobing</creatorcontrib><creatorcontrib>Du, Qin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in cellular and infection microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jia, Shuxian</au><au>Li, Xiaobing</au><au>Du, Qin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Host insulin resistance caused by Porphyromonas gingivalis -review of recent progresses</atitle><jtitle>Frontiers in cellular and infection microbiology</jtitle><addtitle>Front Cell Infect Microbiol</addtitle><date>2023-07-13</date><risdate>2023</risdate><volume>13</volume><spage>1209381</spage><pages>1209381-</pages><issn>2235-2988</issn><eissn>2235-2988</eissn><abstract>is a Gram-negative oral anaerobic bacterium that plays a key role in the pathogenesis of periodontitis.
expresses a variety of virulence factors that disrupt innate and adaptive immunity, allowing
to survive and multiply in the host and destroy periodontal tissue. In addition to periodontal disease,
is also associated with systemic diseases, of which insulin resistance is an important pathological basis.
causes a systemic inflammatory response, disrupts insulin signaling pathways, induces pancreatic β-cell hypofunction and reduced numbers, and causes decreased insulin sensitivity leading to insulin resistance (IR). In this paper, we systematically review the studies on the mechanism of insulin resistance induced by
, discuss the association between
and systemic diseases based on insulin resistance, and finally propose relevant therapeutic approaches. Overall, through a systematic review of the mechanisms related to systemic diseases caused by
through insulin resistance, we hope to provide new insights for future basic research and clinical interventions for related systemic diseases.</abstract><cop>Switzerland</cop><pub>Frontiers Media S.A</pub><pmid>37520442</pmid><doi>10.3389/fcimb.2023.1209381</doi><oa>free_for_read</oa></addata></record> |
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| source | PubMed (Medline) |
| subjects | Alzheimer’s disease Base Composition Cellular and Infection Microbiology diabetes FFA Humans Insulin Insulin Resistance Phylogeny Porphyromonas gingivalis RNA, Ribosomal, 16S Sequence Analysis, DNA |
| title | Host insulin resistance caused by Porphyromonas gingivalis -review of recent progresses |
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