Loading…

Virulence of Marburg Virus Angola Compared to Mt. Elgon (Musoke) in Macaques: A Pooled Survival Analysis

Angola variant (MARV/Ang) has replaced Mt. Elgon variant Musoke isolate (MARV/MtE-Mus) as the consensus standard variant for Marburg virus research and is regarded as causing a more aggressive phenotype of disease in animal models; however, there is a dearth of published evidence supporting the high...

Full description

Saved in:
Bibliographic Details
Published in:Viruses 2018-11, Vol.10 (11), p.658
Main Authors: Blair, Paul W, Keshtkar-Jahromi, Maryam, Psoter, Kevin J, Reisler, Ronald B, Warren, Travis K, Johnston, Sara C, Goff, Arthur J, Downey, Lydia G, Bavari, Sina, Cardile, Anthony P
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c469t-3729a5974ec78df3e3e3a54926f94fe4a6d9b41f018d8654aabd2d99814471603
cites cdi_FETCH-LOGICAL-c469t-3729a5974ec78df3e3e3a54926f94fe4a6d9b41f018d8654aabd2d99814471603
container_end_page
container_issue 11
container_start_page 658
container_title Viruses
container_volume 10
creator Blair, Paul W
Keshtkar-Jahromi, Maryam
Psoter, Kevin J
Reisler, Ronald B
Warren, Travis K
Johnston, Sara C
Goff, Arthur J
Downey, Lydia G
Bavari, Sina
Cardile, Anthony P
description Angola variant (MARV/Ang) has replaced Mt. Elgon variant Musoke isolate (MARV/MtE-Mus) as the consensus standard variant for Marburg virus research and is regarded as causing a more aggressive phenotype of disease in animal models; however, there is a dearth of published evidence supporting the higher virulence of MARV/Ang. In this retrospective study, we used data pooled from eight separate studies in nonhuman primates experimentally exposed with either 1000 pfu intramuscular (IM) MARV/Ang or MARV/MtE-Mus between 2012 and 2017 at the United States Army Medical Research Institute of Infectious Diseases (USAMRIID). Multivariable Cox proportional hazards regression was used to evaluate the association of variant type with time to death, the development of anorexia, rash, viremia, and 10 select clinical laboratory values. A total of 47 cynomolgus monkeys were included, of which 18 were exposed to MARV/Ang in three separate studies and 29 to MARV/MtE-Mus in five studies. Following universally fatal Marburg virus exposure, compared to MARV/MtE-Mus, MARV/Ang was associated with an increased risk of death (HR = 22.10; 95% CI: 7.08, 68.93), rash (HR = 5.87; 95% CI: 2.76, 12.51) and loss of appetite (HR = 35.10; 95% CI: 7.60, 162.18). Our data demonstrate an increased virulence of MARV/Ang compared to MARV/MtE-Mus variant in the 1000 pfu IM cynomolgus macaque model.
doi_str_mv 10.3390/v10110658
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_2ffac7bcf6334d6b99fa261f49906646</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_2ffac7bcf6334d6b99fa261f49906646</doaj_id><sourcerecordid>2137479116</sourcerecordid><originalsourceid>FETCH-LOGICAL-c469t-3729a5974ec78df3e3e3a54926f94fe4a6d9b41f018d8654aabd2d99814471603</originalsourceid><addsrcrecordid>eNpdkk1v1DAQhiMEoqVw4A8gS1zawxY7dpwMB6TVqkClrkDi42pN_JFm8caLnazUf4_DllWLfLA1fv3MzOspiteMXnIO9N2eUcaorJonxSkDgIUAVj19cD4pXqS0oVRKoPXz4oRTIYFLelrc_uzj5O2gLQmOrDG2U-zIHExkOXTBI1mF7Q6jNWQMZD1ekivfhYGcr6cUftkL0g_5mcbfk03vyZJ8DcFn7bcp7vs9-gxBf5f69LJ45tAn--p-Pyt-fLz6vvq8uPny6Xq1vFnoXNK44HUJWEEtrK4b47jNCysBpXQgnBUoDbSCOcoa08hKILamNAANE6JmkvKz4vrANQE3ahf7LcY7FbBXfwMhdgrj2GtvVekc6rrVTnIujGwBHJaSOQGQnRIysz4cWLup3Vqj7TBG9I-gj2-G_lZ1Ya9kKWtJmww4vwfEMBs0qm2ftPUeBxumpErGa1EDY3Out_9JN2GK2bysqpoSytzg3N3FQaVjSCladyyGUTXPgjrOQta-eVj9Ufnv8_kfhp-tBQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2582921440</pqid></control><display><type>article</type><title>Virulence of Marburg Virus Angola Compared to Mt. Elgon (Musoke) in Macaques: A Pooled Survival Analysis</title><source>Publicly Available Content Database</source><source>PubMed Central(OpenAccess)</source><creator>Blair, Paul W ; Keshtkar-Jahromi, Maryam ; Psoter, Kevin J ; Reisler, Ronald B ; Warren, Travis K ; Johnston, Sara C ; Goff, Arthur J ; Downey, Lydia G ; Bavari, Sina ; Cardile, Anthony P</creator><creatorcontrib>Blair, Paul W ; Keshtkar-Jahromi, Maryam ; Psoter, Kevin J ; Reisler, Ronald B ; Warren, Travis K ; Johnston, Sara C ; Goff, Arthur J ; Downey, Lydia G ; Bavari, Sina ; Cardile, Anthony P</creatorcontrib><description>Angola variant (MARV/Ang) has replaced Mt. Elgon variant Musoke isolate (MARV/MtE-Mus) as the consensus standard variant for Marburg virus research and is regarded as causing a more aggressive phenotype of disease in animal models; however, there is a dearth of published evidence supporting the higher virulence of MARV/Ang. In this retrospective study, we used data pooled from eight separate studies in nonhuman primates experimentally exposed with either 1000 pfu intramuscular (IM) MARV/Ang or MARV/MtE-Mus between 2012 and 2017 at the United States Army Medical Research Institute of Infectious Diseases (USAMRIID). Multivariable Cox proportional hazards regression was used to evaluate the association of variant type with time to death, the development of anorexia, rash, viremia, and 10 select clinical laboratory values. A total of 47 cynomolgus monkeys were included, of which 18 were exposed to MARV/Ang in three separate studies and 29 to MARV/MtE-Mus in five studies. Following universally fatal Marburg virus exposure, compared to MARV/MtE-Mus, MARV/Ang was associated with an increased risk of death (HR = 22.10; 95% CI: 7.08, 68.93), rash (HR = 5.87; 95% CI: 2.76, 12.51) and loss of appetite (HR = 35.10; 95% CI: 7.60, 162.18). Our data demonstrate an increased virulence of MARV/Ang compared to MARV/MtE-Mus variant in the 1000 pfu IM cynomolgus macaque model.</description><identifier>ISSN: 1999-4915</identifier><identifier>EISSN: 1999-4915</identifier><identifier>DOI: 10.3390/v10110658</identifier><identifier>PMID: 30469360</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Angola ; animal ; Animal models ; Animals ; Anorexia ; Appetite loss ; Clinical trials ; Disease ; Disease Models, Animal ; Ebola virus ; Epidemics ; Exanthema ; Experiments ; Fatalities ; FDA approval ; Filoviridae ; hemorrhagic fevers ; Infectious diseases ; Injections, Intramuscular ; Laboratory animals ; Macaca ; Marburg disease ; Marburg virus disease ; Marburg Virus Disease - pathology ; Marburgvirus ; Marburgvirus - pathogenicity ; Medical laboratories ; Medical research ; mononegavirales ; Musoke ; Phenotypes ; Product development ; Retrospective Studies ; Survival Analysis ; United States ; Vaccines ; viral ; Viremia ; Virulence ; Viruses</subject><ispartof>Viruses, 2018-11, Vol.10 (11), p.658</ispartof><rights>2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-3729a5974ec78df3e3e3a54926f94fe4a6d9b41f018d8654aabd2d99814471603</citedby><cites>FETCH-LOGICAL-c469t-3729a5974ec78df3e3e3a54926f94fe4a6d9b41f018d8654aabd2d99814471603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2582921440/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2582921440?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30469360$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blair, Paul W</creatorcontrib><creatorcontrib>Keshtkar-Jahromi, Maryam</creatorcontrib><creatorcontrib>Psoter, Kevin J</creatorcontrib><creatorcontrib>Reisler, Ronald B</creatorcontrib><creatorcontrib>Warren, Travis K</creatorcontrib><creatorcontrib>Johnston, Sara C</creatorcontrib><creatorcontrib>Goff, Arthur J</creatorcontrib><creatorcontrib>Downey, Lydia G</creatorcontrib><creatorcontrib>Bavari, Sina</creatorcontrib><creatorcontrib>Cardile, Anthony P</creatorcontrib><title>Virulence of Marburg Virus Angola Compared to Mt. Elgon (Musoke) in Macaques: A Pooled Survival Analysis</title><title>Viruses</title><addtitle>Viruses</addtitle><description>Angola variant (MARV/Ang) has replaced Mt. Elgon variant Musoke isolate (MARV/MtE-Mus) as the consensus standard variant for Marburg virus research and is regarded as causing a more aggressive phenotype of disease in animal models; however, there is a dearth of published evidence supporting the higher virulence of MARV/Ang. In this retrospective study, we used data pooled from eight separate studies in nonhuman primates experimentally exposed with either 1000 pfu intramuscular (IM) MARV/Ang or MARV/MtE-Mus between 2012 and 2017 at the United States Army Medical Research Institute of Infectious Diseases (USAMRIID). Multivariable Cox proportional hazards regression was used to evaluate the association of variant type with time to death, the development of anorexia, rash, viremia, and 10 select clinical laboratory values. A total of 47 cynomolgus monkeys were included, of which 18 were exposed to MARV/Ang in three separate studies and 29 to MARV/MtE-Mus in five studies. Following universally fatal Marburg virus exposure, compared to MARV/MtE-Mus, MARV/Ang was associated with an increased risk of death (HR = 22.10; 95% CI: 7.08, 68.93), rash (HR = 5.87; 95% CI: 2.76, 12.51) and loss of appetite (HR = 35.10; 95% CI: 7.60, 162.18). Our data demonstrate an increased virulence of MARV/Ang compared to MARV/MtE-Mus variant in the 1000 pfu IM cynomolgus macaque model.</description><subject>Angola</subject><subject>animal</subject><subject>Animal models</subject><subject>Animals</subject><subject>Anorexia</subject><subject>Appetite loss</subject><subject>Clinical trials</subject><subject>Disease</subject><subject>Disease Models, Animal</subject><subject>Ebola virus</subject><subject>Epidemics</subject><subject>Exanthema</subject><subject>Experiments</subject><subject>Fatalities</subject><subject>FDA approval</subject><subject>Filoviridae</subject><subject>hemorrhagic fevers</subject><subject>Infectious diseases</subject><subject>Injections, Intramuscular</subject><subject>Laboratory animals</subject><subject>Macaca</subject><subject>Marburg disease</subject><subject>Marburg virus disease</subject><subject>Marburg Virus Disease - pathology</subject><subject>Marburgvirus</subject><subject>Marburgvirus - pathogenicity</subject><subject>Medical laboratories</subject><subject>Medical research</subject><subject>mononegavirales</subject><subject>Musoke</subject><subject>Phenotypes</subject><subject>Product development</subject><subject>Retrospective Studies</subject><subject>Survival Analysis</subject><subject>United States</subject><subject>Vaccines</subject><subject>viral</subject><subject>Viremia</subject><subject>Virulence</subject><subject>Viruses</subject><issn>1999-4915</issn><issn>1999-4915</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkk1v1DAQhiMEoqVw4A8gS1zawxY7dpwMB6TVqkClrkDi42pN_JFm8caLnazUf4_DllWLfLA1fv3MzOspiteMXnIO9N2eUcaorJonxSkDgIUAVj19cD4pXqS0oVRKoPXz4oRTIYFLelrc_uzj5O2gLQmOrDG2U-zIHExkOXTBI1mF7Q6jNWQMZD1ekivfhYGcr6cUftkL0g_5mcbfk03vyZJ8DcFn7bcp7vs9-gxBf5f69LJ45tAn--p-Pyt-fLz6vvq8uPny6Xq1vFnoXNK44HUJWEEtrK4b47jNCysBpXQgnBUoDbSCOcoa08hKILamNAANE6JmkvKz4vrANQE3ahf7LcY7FbBXfwMhdgrj2GtvVekc6rrVTnIujGwBHJaSOQGQnRIysz4cWLup3Vqj7TBG9I-gj2-G_lZ1Ya9kKWtJmww4vwfEMBs0qm2ftPUeBxumpErGa1EDY3Out_9JN2GK2bysqpoSytzg3N3FQaVjSCladyyGUTXPgjrOQta-eVj9Ufnv8_kfhp-tBQ</recordid><startdate>20181121</startdate><enddate>20181121</enddate><creator>Blair, Paul W</creator><creator>Keshtkar-Jahromi, Maryam</creator><creator>Psoter, Kevin J</creator><creator>Reisler, Ronald B</creator><creator>Warren, Travis K</creator><creator>Johnston, Sara C</creator><creator>Goff, Arthur J</creator><creator>Downey, Lydia G</creator><creator>Bavari, Sina</creator><creator>Cardile, Anthony P</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20181121</creationdate><title>Virulence of Marburg Virus Angola Compared to Mt. Elgon (Musoke) in Macaques: A Pooled Survival Analysis</title><author>Blair, Paul W ; Keshtkar-Jahromi, Maryam ; Psoter, Kevin J ; Reisler, Ronald B ; Warren, Travis K ; Johnston, Sara C ; Goff, Arthur J ; Downey, Lydia G ; Bavari, Sina ; Cardile, Anthony P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-3729a5974ec78df3e3e3a54926f94fe4a6d9b41f018d8654aabd2d99814471603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Angola</topic><topic>animal</topic><topic>Animal models</topic><topic>Animals</topic><topic>Anorexia</topic><topic>Appetite loss</topic><topic>Clinical trials</topic><topic>Disease</topic><topic>Disease Models, Animal</topic><topic>Ebola virus</topic><topic>Epidemics</topic><topic>Exanthema</topic><topic>Experiments</topic><topic>Fatalities</topic><topic>FDA approval</topic><topic>Filoviridae</topic><topic>hemorrhagic fevers</topic><topic>Infectious diseases</topic><topic>Injections, Intramuscular</topic><topic>Laboratory animals</topic><topic>Macaca</topic><topic>Marburg disease</topic><topic>Marburg virus disease</topic><topic>Marburg Virus Disease - pathology</topic><topic>Marburgvirus</topic><topic>Marburgvirus - pathogenicity</topic><topic>Medical laboratories</topic><topic>Medical research</topic><topic>mononegavirales</topic><topic>Musoke</topic><topic>Phenotypes</topic><topic>Product development</topic><topic>Retrospective Studies</topic><topic>Survival Analysis</topic><topic>United States</topic><topic>Vaccines</topic><topic>viral</topic><topic>Viremia</topic><topic>Virulence</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blair, Paul W</creatorcontrib><creatorcontrib>Keshtkar-Jahromi, Maryam</creatorcontrib><creatorcontrib>Psoter, Kevin J</creatorcontrib><creatorcontrib>Reisler, Ronald B</creatorcontrib><creatorcontrib>Warren, Travis K</creatorcontrib><creatorcontrib>Johnston, Sara C</creatorcontrib><creatorcontrib>Goff, Arthur J</creatorcontrib><creatorcontrib>Downey, Lydia G</creatorcontrib><creatorcontrib>Bavari, Sina</creatorcontrib><creatorcontrib>Cardile, Anthony P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest - Health &amp; Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Viruses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blair, Paul W</au><au>Keshtkar-Jahromi, Maryam</au><au>Psoter, Kevin J</au><au>Reisler, Ronald B</au><au>Warren, Travis K</au><au>Johnston, Sara C</au><au>Goff, Arthur J</au><au>Downey, Lydia G</au><au>Bavari, Sina</au><au>Cardile, Anthony P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Virulence of Marburg Virus Angola Compared to Mt. Elgon (Musoke) in Macaques: A Pooled Survival Analysis</atitle><jtitle>Viruses</jtitle><addtitle>Viruses</addtitle><date>2018-11-21</date><risdate>2018</risdate><volume>10</volume><issue>11</issue><spage>658</spage><pages>658-</pages><issn>1999-4915</issn><eissn>1999-4915</eissn><abstract>Angola variant (MARV/Ang) has replaced Mt. Elgon variant Musoke isolate (MARV/MtE-Mus) as the consensus standard variant for Marburg virus research and is regarded as causing a more aggressive phenotype of disease in animal models; however, there is a dearth of published evidence supporting the higher virulence of MARV/Ang. In this retrospective study, we used data pooled from eight separate studies in nonhuman primates experimentally exposed with either 1000 pfu intramuscular (IM) MARV/Ang or MARV/MtE-Mus between 2012 and 2017 at the United States Army Medical Research Institute of Infectious Diseases (USAMRIID). Multivariable Cox proportional hazards regression was used to evaluate the association of variant type with time to death, the development of anorexia, rash, viremia, and 10 select clinical laboratory values. A total of 47 cynomolgus monkeys were included, of which 18 were exposed to MARV/Ang in three separate studies and 29 to MARV/MtE-Mus in five studies. Following universally fatal Marburg virus exposure, compared to MARV/MtE-Mus, MARV/Ang was associated with an increased risk of death (HR = 22.10; 95% CI: 7.08, 68.93), rash (HR = 5.87; 95% CI: 2.76, 12.51) and loss of appetite (HR = 35.10; 95% CI: 7.60, 162.18). Our data demonstrate an increased virulence of MARV/Ang compared to MARV/MtE-Mus variant in the 1000 pfu IM cynomolgus macaque model.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>30469360</pmid><doi>10.3390/v10110658</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1999-4915
ispartof Viruses, 2018-11, Vol.10 (11), p.658
issn 1999-4915
1999-4915
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_2ffac7bcf6334d6b99fa261f49906646
source Publicly Available Content Database; PubMed Central(OpenAccess)
subjects Angola
animal
Animal models
Animals
Anorexia
Appetite loss
Clinical trials
Disease
Disease Models, Animal
Ebola virus
Epidemics
Exanthema
Experiments
Fatalities
FDA approval
Filoviridae
hemorrhagic fevers
Infectious diseases
Injections, Intramuscular
Laboratory animals
Macaca
Marburg disease
Marburg virus disease
Marburg Virus Disease - pathology
Marburgvirus
Marburgvirus - pathogenicity
Medical laboratories
Medical research
mononegavirales
Musoke
Phenotypes
Product development
Retrospective Studies
Survival Analysis
United States
Vaccines
viral
Viremia
Virulence
Viruses
title Virulence of Marburg Virus Angola Compared to Mt. Elgon (Musoke) in Macaques: A Pooled Survival Analysis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T08%3A44%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Virulence%20of%20Marburg%20Virus%20Angola%20Compared%20to%20Mt.%20Elgon%20(Musoke)%20in%20Macaques:%20A%20Pooled%20Survival%20Analysis&rft.jtitle=Viruses&rft.au=Blair,%20Paul%20W&rft.date=2018-11-21&rft.volume=10&rft.issue=11&rft.spage=658&rft.pages=658-&rft.issn=1999-4915&rft.eissn=1999-4915&rft_id=info:doi/10.3390/v10110658&rft_dat=%3Cproquest_doaj_%3E2137479116%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c469t-3729a5974ec78df3e3e3a54926f94fe4a6d9b41f018d8654aabd2d99814471603%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2582921440&rft_id=info:pmid/30469360&rfr_iscdi=true