Brain and heart‐specific death in cancer patients: Population‐based study

• Published in: Cancer medicine (Malden, MA) MA), 2021-09, Vol.10 (17), p.5739-5747
• Main Authors: Safi, Mohammed, Al‐Nusaif, Murad, Trapani, Dario, Mashrah, Mubarak A, Kanesvaran, Ravindran, Alzandani, Aziz, Al‐Azab, Mahmoud, Mazher, Syed A, Al‐Danakh, Abdullah, Liu, Jiwei
• Format: Article
• Language: English
• Subjects: Adult; Aged; Alzheimer's disease; Atherosclerosis; Autonomic nervous system; Brain cancer; Brain Death - pathology; brain metastases; brain–heart axis; Cancer therapies; Chemotherapy; Clinical Cancer Research; Death; Epidemiology; Female; Heart; heart block; Histology; Humans; Liver; Lung cancer; Male; Medical prognosis; Metastases; Metastasis; Middle Aged; Multivariate analysis; Neoplasms - complications; Patients; Population; Population studies; Population-based studies; Prognosis; Radiation; SEER Program - standards; Survival; Tumors; Variables; Young Adult
• ISSN: 2045-7634; 2045-7634
• DOI: 10.1002/cam4.4069

Background The occurrence of cardiovascular events is a major cause of death in patients with cancer. Small studies have documented a connection between specific brain alterations and autonomic cardiac dysfunctions, possibly resulting in a worse prognosis. We aimed to refine the knowledge of fatal cardiac events in patients with brain metastasis (BM). Methods We performed a Surveillance, Epidemiology, and End Results SEER registry‐based investigation (timeline: 2010–2016) and extracted all the advanced patients who had experienced fatal cardiac outcomes. Populations were compared according to the presence or not BM. Kaplan–Meier (KM) methodology was used for survival analysis and a multivariate model was developed by adjusting for multiple possible confounders. Results Most related BM and cardiac death were observed at the site of lung cancer (81.4%). We extracted 3187 patients with lung cancer site, including 417 patients who had experienced fatal heart‐specific with a history of BM, which is considered a BM group. The second group of heart‐specific death included 2770 patients was stated as a non‐BM group. Patients who had experienced heart‐specific death in the BM group were predominately male, right side, upper site, and non‐small type (62.11%, 54.92%, 51.56%, 69.78%), respectively. The survival outcomes between BM and the non‐ BM was significantly prominent (p = 0.003; median: 2 months vs. 3 months).The negative prognostic independent significance of heart‐fatal events was confirmed after adjusting for multiple variables (HR = 0.76, CI = 0.68–84, p