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Enhanced breast cancer therapy using multifunctional lipid-coated nanoparticles combining curcumin chemotherapy and nitric oxide gas delivery
The limitations associated with conventional cancer treatment modalities, particularly for breast cancer, underscore the imperative for developing safer and more productive drug delivery systems. A promising strategy that has emerged is the combination of chemotherapy with gas therapy. We synthesize...
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| Published in: | Scientific reports 2024-08, Vol.14 (1), p.18107-14, Article 18107 |
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| container_end_page | 14 |
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| creator | Yan, Zhirong Xiao, Peihan Ji, Peng Su, Rongjian Ren, Zhenkun Xu, Li Qiu, Xun Li, Dan |
| description | The limitations associated with conventional cancer treatment modalities, particularly for breast cancer, underscore the imperative for developing safer and more productive drug delivery systems. A promising strategy that has emerged is the combination of chemotherapy with gas therapy. We synthesized curcumin-loaded amorphous calcium carbonate nanoparticles (Cur-CaCO
3
) via a gas diffusion reaction in the present study. Subsequently, a "one-step" ethanol injection method was employed to fabricate lipid-coated calcium carbonate nanoparticles (Cur-CaCO
3
@LA-Lip) loaded with L-arginine, aimed at harnessing the synergistic effects of chemotherapy and nitric oxide to enhance antitumor efficacy. Transmission electron microscopy analysis revealed that Cur-CaCO
3
@LA-Lip nanoparticles were subspherical with a distinct lipid layer encapsulating the periphery. Fourier transform infrared spectroscopy, X-ray powder diffraction, and differential scanning calorimetry results confirmed the successful synthesis of Cur-CaCO
3
@LA-Lip. The nanoparticles exhibited significant drug loading capacities of 8.89% for curcumin and 3.1% for L-arginine. In vitro and in vivo assessments demonstrated that Cur-CaCO
3
@LA-Lip nanoparticles facilitated sustained release of curcumin and exhibited high cellular uptake, substantial tumor accumulation, and excellent biocompatibility. Additionally, the nanoparticles showed robust cytotoxicity and potent antitumor efficacy, suggesting their potential as a formidable candidate for breast cancer therapy. |
| doi_str_mv | 10.1038/s41598-024-69229-2 |
| format | article |
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3
) via a gas diffusion reaction in the present study. Subsequently, a "one-step" ethanol injection method was employed to fabricate lipid-coated calcium carbonate nanoparticles (Cur-CaCO
3
@LA-Lip) loaded with L-arginine, aimed at harnessing the synergistic effects of chemotherapy and nitric oxide to enhance antitumor efficacy. Transmission electron microscopy analysis revealed that Cur-CaCO
3
@LA-Lip nanoparticles were subspherical with a distinct lipid layer encapsulating the periphery. Fourier transform infrared spectroscopy, X-ray powder diffraction, and differential scanning calorimetry results confirmed the successful synthesis of Cur-CaCO
3
@LA-Lip. The nanoparticles exhibited significant drug loading capacities of 8.89% for curcumin and 3.1% for L-arginine. In vitro and in vivo assessments demonstrated that Cur-CaCO
3
@LA-Lip nanoparticles facilitated sustained release of curcumin and exhibited high cellular uptake, substantial tumor accumulation, and excellent biocompatibility. Additionally, the nanoparticles showed robust cytotoxicity and potent antitumor efficacy, suggesting their potential as a formidable candidate for breast cancer therapy.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-024-69229-2</identifier><identifier>PMID: 39103425</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/67/1059 ; 639/301/54/152 ; 692/4028/67/1059 ; 692/4028/67/1347 ; Amorphous calcium carbonate ; Animals ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Antitumor activity ; Arginine ; Arginine - chemistry ; Biocompatibility ; Biocompatible ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - pathology ; Calcium carbonate ; Calcium Carbonate - chemistry ; Calorimetry ; Cancer therapies ; Cell Line, Tumor ; Chemo-gas therapy ; Chemotherapy ; Controlled release ; Curcumin ; Curcumin - administration & dosage ; Curcumin - chemistry ; Curcumin - pharmacology ; Cytotoxicity ; Differential scanning calorimetry ; Drug Carriers - chemistry ; Drug delivery ; Drug delivery system ; Drug Delivery Systems - methods ; Ethanol ; Female ; Fourier transforms ; Humanities and Social Sciences ; Humans ; Infrared spectroscopy ; Lipids ; Lipids - chemistry ; Mice ; multidisciplinary ; Nanoparticles ; Nanoparticles - chemistry ; Nitric oxide ; Nitric Oxide - administration & dosage ; Nitric Oxide - chemistry ; Nitric Oxide - metabolism ; Science ; Science (multidisciplinary) ; Synergistic effect ; Transmission electron microscopy</subject><ispartof>Scientific reports, 2024-08, Vol.14 (1), p.18107-14, Article 18107</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c422t-92b381d9ea6331603840b40efa1ea050dc624f0d52b4c60e3840ad51468c2e943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3089002850/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3089002850?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39103425$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yan, Zhirong</creatorcontrib><creatorcontrib>Xiao, Peihan</creatorcontrib><creatorcontrib>Ji, Peng</creatorcontrib><creatorcontrib>Su, Rongjian</creatorcontrib><creatorcontrib>Ren, Zhenkun</creatorcontrib><creatorcontrib>Xu, Li</creatorcontrib><creatorcontrib>Qiu, Xun</creatorcontrib><creatorcontrib>Li, Dan</creatorcontrib><title>Enhanced breast cancer therapy using multifunctional lipid-coated nanoparticles combining curcumin chemotherapy and nitric oxide gas delivery</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The limitations associated with conventional cancer treatment modalities, particularly for breast cancer, underscore the imperative for developing safer and more productive drug delivery systems. A promising strategy that has emerged is the combination of chemotherapy with gas therapy. We synthesized curcumin-loaded amorphous calcium carbonate nanoparticles (Cur-CaCO
3
) via a gas diffusion reaction in the present study. Subsequently, a "one-step" ethanol injection method was employed to fabricate lipid-coated calcium carbonate nanoparticles (Cur-CaCO
3
@LA-Lip) loaded with L-arginine, aimed at harnessing the synergistic effects of chemotherapy and nitric oxide to enhance antitumor efficacy. Transmission electron microscopy analysis revealed that Cur-CaCO
3
@LA-Lip nanoparticles were subspherical with a distinct lipid layer encapsulating the periphery. Fourier transform infrared spectroscopy, X-ray powder diffraction, and differential scanning calorimetry results confirmed the successful synthesis of Cur-CaCO
3
@LA-Lip. The nanoparticles exhibited significant drug loading capacities of 8.89% for curcumin and 3.1% for L-arginine. In vitro and in vivo assessments demonstrated that Cur-CaCO
3
@LA-Lip nanoparticles facilitated sustained release of curcumin and exhibited high cellular uptake, substantial tumor accumulation, and excellent biocompatibility. 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A promising strategy that has emerged is the combination of chemotherapy with gas therapy. We synthesized curcumin-loaded amorphous calcium carbonate nanoparticles (Cur-CaCO
3
) via a gas diffusion reaction in the present study. Subsequently, a "one-step" ethanol injection method was employed to fabricate lipid-coated calcium carbonate nanoparticles (Cur-CaCO
3
@LA-Lip) loaded with L-arginine, aimed at harnessing the synergistic effects of chemotherapy and nitric oxide to enhance antitumor efficacy. Transmission electron microscopy analysis revealed that Cur-CaCO
3
@LA-Lip nanoparticles were subspherical with a distinct lipid layer encapsulating the periphery. Fourier transform infrared spectroscopy, X-ray powder diffraction, and differential scanning calorimetry results confirmed the successful synthesis of Cur-CaCO
3
@LA-Lip. The nanoparticles exhibited significant drug loading capacities of 8.89% for curcumin and 3.1% for L-arginine. In vitro and in vivo assessments demonstrated that Cur-CaCO
3
@LA-Lip nanoparticles facilitated sustained release of curcumin and exhibited high cellular uptake, substantial tumor accumulation, and excellent biocompatibility. Additionally, the nanoparticles showed robust cytotoxicity and potent antitumor efficacy, suggesting their potential as a formidable candidate for breast cancer therapy.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>39103425</pmid><doi>10.1038/s41598-024-69229-2</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/67/1059 639/301/54/152 692/4028/67/1059 692/4028/67/1347 Amorphous calcium carbonate Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity Arginine Arginine - chemistry Biocompatibility Biocompatible Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - pathology Calcium carbonate Calcium Carbonate - chemistry Calorimetry Cancer therapies Cell Line, Tumor Chemo-gas therapy Chemotherapy Controlled release Curcumin Curcumin - administration & dosage Curcumin - chemistry Curcumin - pharmacology Cytotoxicity Differential scanning calorimetry Drug Carriers - chemistry Drug delivery Drug delivery system Drug Delivery Systems - methods Ethanol Female Fourier transforms Humanities and Social Sciences Humans Infrared spectroscopy Lipids Lipids - chemistry Mice multidisciplinary Nanoparticles Nanoparticles - chemistry Nitric oxide Nitric Oxide - administration & dosage Nitric Oxide - chemistry Nitric Oxide - metabolism Science Science (multidisciplinary) Synergistic effect Transmission electron microscopy |
| title | Enhanced breast cancer therapy using multifunctional lipid-coated nanoparticles combining curcumin chemotherapy and nitric oxide gas delivery |
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