BDNF Actions in the Cardiovascular System: Roles in Development, Adulthood and Response to Injury

The actions of BDNF (Brain-derived Neurotrophic Factor) in regulating neuronal development and modulating synaptic activity have been extensively studied and well established. Equally important roles for this growth factor have been uncovered in the cardiovascular system, through the examination of...

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Bibliographic Details
Published in:Frontiers in physiology 2019-04, Vol.10, p.455-455
Main Authors: Kermani, Pouneh, Hempstead, Barbara
Format: Article
Language:English
Subjects:
BDNF
cardiovascular system
myocardial infarction
myocyte
Physiology
TrkB
vascular injury
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Summary:The actions of BDNF (Brain-derived Neurotrophic Factor) in regulating neuronal development and modulating synaptic activity have been extensively studied and well established. Equally important roles for this growth factor have been uncovered in the cardiovascular system, through the examination of gene targeted animals to define critical actions in development, and to the unexpected roles of BDNF in modulating the response of the heart and vasculature to injury. Here we review the compartmentally distinct realm of cardiac myocytes, vascular smooth muscle cells, endothelial cells, and hematopoietic cells, focusing upon the actions of BDNF to modulate contractility, migration, neoangiogenesis, apoptosis and survival. These studies indicate that BDNF is an important growth factor which directs the response of the cardiovascular system to acute and chronic injury.
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2019.00455