Glycemic Index, Glycemic Load, and FAS rs6586161 Polymorphism in Relation to Gastric Cancer Risk: A Case-Control Study in Korea

Many dietary and genetic factors have been confirmed to be associated with gastric cancer risk. This research investigated gastric cancer risk with regard to the glycemic index, glycemic load, and FAS rs6586161 polymorphism. A total of 232 matched pairs were included in this case-control study. Data...

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Bibliographic Details
Published in:Nutrients 2023-07, Vol.15 (14), p.3238
Main Authors: Kim, Hong Kyoung, Kim, Sang Young, Kwak, Jung Hyun, Kim, Hyun Ja
Format: Article
Language:English
Subjects:
Alcohol use
Apoptosis
Body mass index
Cancer
Carbohydrates
case-control study
Cell growth
Data collection
Diet
DNA methylation
Energy consumption
FAS
Food
Gastric cancer
Genes
Genetic aspects
Glucose
Glycemic index
glycemic load
Health aspects
Infections
Middle schools
Nutrition research
Oncology, Experimental
Polymorphism
Regression analysis
Risk factors
single-nucleotide polymorphisms
Stomach cancer
Surveys
Thoracic surgery
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Summary:Many dietary and genetic factors have been confirmed to be associated with gastric cancer risk. This research investigated gastric cancer risk with regard to the glycemic index, glycemic load, and FAS rs6586161 polymorphism. A total of 232 matched pairs were included in this case-control study. Data collection was conducted at two hospitals in Korea from 2002 to 2006. Dietary information was obtained from a food frequency questionnaire, and genotypes of FAS rs6586161 polymorphism were TT, TA, and AA type. Gastric cancer risk was increased for the highest tertile of glycemic index (vs. lowest tertile, OR = 1.84, 95% CI = 1.07-3.18), the highest tertile of glycemic load (vs. lowest tertile, OR = 2.14, 95% CI = 1.23-3.75), and the AA type of FAS rs6586161 polymorphism (vs. TT types, OR = 1.95, 95% CI = 1.13-3.39). Furthermore, gastric cancer risk was significantly elevated for the participants with the highest glycemic load and AA type of FAS rs6586161 polymorphism (vs. the lowest glycemic load and TT type, OR = 5.53, 95% CI = 2.01-15.21). Both the high glycemic load and AA type of FAS rs6586161 polymorphism increased gastric cancer risk; however, the interactions between these two elevated the risk of gastric cancer even more.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15143238