Impact of COVID-19 on Pregnancy Outcomes across Trimesters in the United States

Background: Current knowledge regarding the association between trimester-specific changes during pregnancy and COVID-19 infection is limited. We utilized the National Inpatient Sample (NIS) database to investigate trimester-specific outcomes among hospitalized pregnant women diagnosed with COVID-19...

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Published in:Biomedicines 2023-10, Vol.11 (11), p.2886
Main Authors: Virk, Shiza, Gangu, Karthik, Nasrullah, Adeel, Shah, Aaisha, Faiz, Zohaa, Khan, Umair, Jackson, David Bradley, Javed, Anam, Farooq, Asif, DiSilvio, Briana, Cheema, Tariq, Sheikh, Abu Baker
Format: Article
Language:English
Subjects:
complications
Coronaviruses
COVID-19
Fetuses
Health aspects
Hispanic American women
Infants (Premature)
Infection
Mechanical ventilation
Mortality
Pre-eclampsia
Pregnancy
Pregnancy complications
Pregnant women
Premature birth
racial disparities
trimester-specific outcomes
Vein & artery diseases
Womens health
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Summary:Background: Current knowledge regarding the association between trimester-specific changes during pregnancy and COVID-19 infection is limited. We utilized the National Inpatient Sample (NIS) database to investigate trimester-specific outcomes among hospitalized pregnant women diagnosed with COVID-19. Results: Out of 3,447,771 pregnant women identified, those with COVID-19 exhibited higher in-hospital mortality rates in their third trimester compared with those without the virus. Notably, rates of mechanical ventilation, acute kidney injury, renal replacement therapy, and perinatal complications (preeclampsia, HELLP syndrome, and preterm birth) were significantly elevated across all trimesters for COVID-19 patients. COVID-19 was found to be more prevalent among low-income, Hispanic pregnant women. Conclusions: Our findings suggest that COVID-19 during pregnancy is associated with increased risk of maternal mortality and complications, particularly in the third trimester. Furthermore, we observed significant racial and socioeconomic disparities in both COVID-19 prevalence and pregnancy outcomes. These findings emphasize the need for equitable healthcare strategies to improve care for diverse and socioeconomically marginalized groups, ultimately aiming to reduce adverse COVID-19-associated maternal and fetal outcomes.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11112886