Survival analysis in patients with metastatic spinal disease: the influence of surgery, histology, clinical and neurologic status

Spine is the most common site for skeletal metastasis in patients with malignancy. Vertebral involvement quantification, neurological status, general health status and primary tumor histology are factors to set surgical planning and therapeutic targets. We evaluated the impact of general clinical an...

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Bibliographic Details
Published in:Arquivos de neuro-psiquiatria 2015-04, Vol.73 (4), p.330-335
Main Authors: Oliveira, Matheus Fernandes de, Rotta, Jose Marcus, Botelho, Ricardo Vieira
Format: Article
Language:English
Subjects:
Aged
Breast Neoplasms - mortality
Breast Neoplasms - pathology
doenças espinhais
Female
Humans
Kaplan-Meier Estimate
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Lymphoma - mortality
Lymphoma - pathology
Male
metástases
Middle Aged
Multiple Myeloma - mortality
Multiple Myeloma - pathology
NEUROSCIENCES
Pleural Neoplasms - mortality
Pleural Neoplasms - pathology
Prognosis
prognóstico
Prostatic Neoplasms - mortality
Prostatic Neoplasms - pathology
PSYCHIATRY
Spinal Neoplasms - mortality
Spinal Neoplasms - secondary
Spinal Neoplasms - therapy
Statistics, Nonparametric
Survival Rate
Time Factors
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Summary:Spine is the most common site for skeletal metastasis in patients with malignancy. Vertebral involvement quantification, neurological status, general health status and primary tumor histology are factors to set surgical planning and therapeutic targets. We evaluated the impact of general clinical and neurological status, histologic type and surgery in survival. The study sample consisted of consecutive patients admitted from July 2010 to January 2013 for treatment. Sixty eight patients were evaluated. 23 were female and 45 were male. Main primary neoplasic sites were: breast, prostate, lung/pleura and linfoproliferative. Thirty three out of 68 received surgical treatment, 2 received percutaneous biopsy and 33 had nonsurgical treatment. Log Rank curves revealed no statistical significant difference according to histological type, surgical approach and Frankel Score. Karnofsky Score was statistically different. Histological type and clinical status were statistically associated with life expectancy in vertebral metastatic disease.
ISSN:0004-282X
1678-4227
1678-4227
0004-282X
DOI:10.1590/0004-282X20150003