In Vivo Rodent Models of Type 2 Diabetes and Their Usefulness for Evaluating Flavonoid Bioactivity

About 40% of the world's population is overweight or obese and exist at risk of developing type 2 diabetes mellitus (T2D). Obesity is a leading pathogenic factor for developing insulin resistance (IR). It is well established that IR and a progressive decline in functional β-cell mass are hallma...

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Bibliographic Details
Published in:Nutrients 2019-02, Vol.11 (3), p.530
Main Authors: Fang, Jia-You, Lin, Chih-Hung, Huang, Tse-Hung, Chuang, Shih-Yi
Format: Article
Language:English
Subjects:
Analysis
animal model
Animal models
Animals
antioxidant
Beta cells
Biological activity
Body weight
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - drug therapy
Dietary intake
Disease Models, Animal
Dogs
flavonoid
Flavonoids
Flavonoids - therapeutic use
Genetic engineering
Glucose
Hogs
Homeostasis
Hyperglycemia
Insects
Insulin
Insulin resistance
Isoflavones
Laboratories
Metabolism
Metronidazole
Molecular modelling
Monkeys & apes
Mutation
Obesity
Pancreas
Peptides
Physiology
Polyphenols
Primates
Resistance factors
Review
Rodentia
Rodents
Type 2 diabetes
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Summary:About 40% of the world's population is overweight or obese and exist at risk of developing type 2 diabetes mellitus (T2D). Obesity is a leading pathogenic factor for developing insulin resistance (IR). It is well established that IR and a progressive decline in functional β-cell mass are hallmarks of developing T2D. In order to mitigate the global prevalence of T2D, we must carefully select the appropriate animal models to explore the cellular and molecular mechanisms of T2D, and to optimize novel therapeutics for their safe use in humans. Flavonoids, a group of polyphenols, have drawn great interest for their various health benefits, and have been identified in naturally occurring anti-diabetic compounds. Results from many clinical and animal studies demonstrate that dietary intake of flavonoids might prove helpful in preventing T2D. In this review, we discuss the currently available rodent animal models of T2D and analyze the advantages, the limitations of each T2D model, and highlight the potential anti-diabetic effects of flavonoids as well as the mechanisms of their actions.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu11030530