Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery Phase

Using a specific enzyme-linked immunosorbent assay, IL-10 concentrations were measured in serum from 62 patients with ulcerative colitis (UC), 43 with Crohn's disease (CD), 25 with other colitides, and 44 normal control subjects. Serum IL-10 concentrations were increased in patients with active...

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Bibliographic Details
Published in:Mediators of Inflammation 2006-01, Vol.2006 (6), p.112-118
Main Authors: MITSUYAMA, Keiichi, TOMIYASU, Nobuo, TAKAKI, Kosuke, MASUDA, Junya, YAMASAKI, Hiroshi, KUWAKI, Kotaro, TAKEDA, Teiko, KITAZAKI, Shigehiko, TSURUTA, Osamu, SATA, Michio
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
C-Reactive Protein - analysis
Care and treatment
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Inflammatory bowel diseases
Inflammatory Bowel Diseases - blood
Inflammatory Bowel Diseases - physiopathology
Interleukin-10
Interleukin-10 - blood
Interleukin-6 - blood
Male
Medical sciences
Other diseases. Semiology
Physiology, Pathological
Reference Values
Research Communication
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Summary:Using a specific enzyme-linked immunosorbent assay, IL-10 concentrations were measured in serum from 62 patients with ulcerative colitis (UC), 43 with Crohn's disease (CD), 25 with other colitides, and 44 normal control subjects. Serum IL-10 concentrations were increased in patients with active UC but not in those with active CD when compared with normal control subjects. A time course study showed that in patients with UC and CD, serum concentrations of IL-6 and C-reactive protein increased during the acute phase and returned to normal as patients go into remission. Notably, serum IL-10 concentrations increased during the phase of disease resolution and declined thereafter regardless of the treatment modality. Gel filtration analysis indicated that IL-10 circulated predominantly as a dimer. In conclusion, this study shows that serum IL-10 is increased during disease recovery in patients with inflammatory bowel disease, and may be a helpful marker in monitoring disease status.
ISSN:0962-9351
1466-1861
DOI:10.1155/MI/2006/26875