Helicobacter pylori outer membrane vesicles involvement in the infection development and Helicobacter pylori-related diseases

Helicobacter pylori - (H. pylori) play a role in the pathogenesis of gastritis, gastric and duodenal ulcers as well as gastric cancer. A possible involvement of outer membrane vesicles (OMVs) produced by H. pylori in the distribution of bacterial antigens through the gastric epithelial barrier and t...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biomedical science 2018-11, Vol.25 (1), p.78-78, Article 78
Main Authors: Chmiela, Magdalena, Walczak, Natalia, Rudnicka, Karolina
Format: Article
Language:English
Subjects:
Antigens
Antigens, Bacterial - metabolism
Apoptosis
Bacteria
Bioactive compounds
Biological activity
Cardiovascular disease
Extracellular Vesicles - metabolism
Gastric cancer
Gastritis
Gastritis - immunology
Gram-negative bacteria
Gram-positive bacteria
Health aspects
Helicobacter Infections - immunology
Helicobacter pylori
Helicobacter pylori - pathogenicity
Helicobacter pylori - physiology
Host-Pathogen Interactions
Immune response
Infections
Inflammation
Ligands
Membrane vesicles
Microbiota
outer membrane vesicles
Pathogenesis
Peptic Ulcer - immunology
Review
Signal Transduction
Ulcers
Vesicles
Virulence
virulence factor
Virulence Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Helicobacter pylori - (H. pylori) play a role in the pathogenesis of gastritis, gastric and duodenal ulcers as well as gastric cancer. A possible involvement of outer membrane vesicles (OMVs) produced by H. pylori in the distribution of bacterial antigens through the gastric epithelial barrier and their role in the development of local and systemic host inflammatory and immune responses has been suggested. OMVs contain various biologically active compounds, which internalize into host cells affecting signaling pathways and promoting apoptosis of gastric epithelial and immunocompetent cells. OMVs-associated H. pylori virulence factors may strengthen or downregulate the immune responses leading to disease development. This review describes the biological importance of H. pylori OMVs and their role in the course of H. pylori infections, as well as H. pylori related local and systemic effects.
ISSN:1423-0127
1021-7770
1423-0127
DOI:10.1186/s12929-018-0480-y