Prevalence of Neonatal Sepsis in Ethiopia: A Systematic Review and Meta-Analysis

Introduction. Neonatal sepsis is a systemic infection occurring in infants during the first 4 weeks of life and is a major cause of mortality and morbidities of newborns due to their age-related weak and immature immune systems. In Ethiopia, despite many studies being conducted on neonatal sepsis, t...

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Bibliographic Details
Published in:International journal of pediatrics 2020, Vol.2020 (2020), p.1-9
Main Authors: Alemu, Simegn, Lamore, Yonas, Ketema, Daniel Bekele, Yismaw, Lieltwork, Alene, Muluneh, Assemie, Moges Agazhe, Petrucka, Pammla
Format: Article
Language:English
Subjects:
Analysis
Ethiopia
Health aspects
Infants (Newborn)
Infection
Mortality
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Summary:Introduction. Neonatal sepsis is a systemic infection occurring in infants during the first 4 weeks of life and is a major cause of mortality and morbidities of newborns due to their age-related weak and immature immune systems. In Ethiopia, despite many studies being conducted on neonatal sepsis, the reported findings are inconsistent. The aim of this study is to determine the prevalence of neonatal sepsis to enhance the utility and interpretation of the evidence. Methods. An extensive systematic review and meta-analysis were performed to extract studies on the prevalence of neonatal sepsis in Ethiopia. The PubMed, Cochrane Library, ScienceDirect, Web of Science, and Google Scholar were systematically searched. Two independent authors selected and extracted the data from each included article. The heterogeneity of included studies was assessed using the Higgins I2 test, and a random-effects model was performed in Stata/se Version 14. Results. Eighteen studies with a sample size of 10,495 study subjects were included with a reported range of neonatal sepsis from 17% to 78%. The pooled prevalence of neonatal sepsis was 45% (95% CI: 35, 55; I2=99.3%, p
ISSN:1687-9740
1687-9759
DOI:10.1155/2020/6468492