Cardiovascular Events Among Survivors of Sepsis Hospitalization: A Retrospective Cohort Analysis

Background Sepsis is associated with an elevated risk of late cardiovascular events among hospital survivors. Methods and Results We included OptumLabs Data Warehouse patients from 2009 to 2019 who survived a medical/nonsurgical hospitalization lasting at least 2 nights. The association between seps...

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Bibliographic Details
Published in:Journal of the American Heart Association 2023-02, Vol.12 (3), p.e027813-e027813
Main Authors: Jentzer, Jacob C, Lawler, Patrick R, Van Houten, Holly K, Yao, Xiaoxi, Kashani, Kianoush B, Dunlay, Shannon M
Format: Article
Language:English
Subjects:
Aftercare
Cohort Studies
heart failure
Heart Failure - complications
Heart Failure - epidemiology
Heart Failure - therapy
Hospitalization
Humans
mortality
myocardial infarction
Original Research
Patient Discharge
Proportional Hazards Models
Retrospective Studies
Risk Factors
sepsis
Sepsis - complications
Survivors
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Summary:Background Sepsis is associated with an elevated risk of late cardiovascular events among hospital survivors. Methods and Results We included OptumLabs Data Warehouse patients from 2009 to 2019 who survived a medical/nonsurgical hospitalization lasting at least 2 nights. The association between sepsis during hospitalization, based on explicit and implicit discharge ( )/ ( ) diagnosis codes, with subsequent death and rehospitalization was analyzed using Kaplan-Meier survival analysis and multivariable Cox proportional-hazards models. The study population included 2 258 464 survivors of nonsurgical hospitalization (5 396 051 total patient-years of follow-up). A total of 808 673 (35.8%) patients had a sepsis hospitalization, including implicit sepsis only in 448 644, explicit sepsis only in 124 841, and both in 235 188. Patients with sepsis during hospitalization had an elevated risk of all-cause mortality (adjusted hazard ratio [HR], 1.27 [95% CI, 1.25-1.28];
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.122.027813