Emerging Insights into the Role of BDNF on Health and Disease in Periphery

Brain-derived neurotrophic factor (BDNF) is a growth factor that promotes the survival and growth of developing neurons. It also enhances circuit formation to synaptic transmission for mature neurons in the brain. However, reduced BDNF expression and single nucleotide polymorphisms (SNP) are reporte...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2024-04, Vol.14 (4), p.444
Main Authors: Ichimura-Shimizu, Mayuko, Kurrey, Khuleshwari, Miyata, Misaki, Dezawa, Takuya, Tsuneyama, Koichi, Kojima, Masami
Format: Article
Language:English
Subjects:
Amino acids
Analysis
Animals
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - genetics
Brain-Derived Neurotrophic Factor - metabolism
Care and treatment
Complications and side effects
Diagnosis
Energy
Energy metabolism
Energy Metabolism - genetics
Fatty liver
Gene expression
Growth factors
Humans
hyperphagia
Hypothalamus
Kinases
Ligands
MASH
MASLD
Metabolic diseases
Metabolic syndrome
Metabolism
Mice
Mice, Knockout
Mutation
Nervous system
Obesity - genetics
Obesity - metabolism
Peptides
Phenotypes
Polymorphism, Single Nucleotide
Proteins
Receptor, trkB - genetics
Receptor, trkB - metabolism
Risk factors
Single nucleotide polymorphisms
Single-nucleotide polymorphism
steatohepatitis
Synaptic transmission
TrkB receptors
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Summary:Brain-derived neurotrophic factor (BDNF) is a growth factor that promotes the survival and growth of developing neurons. It also enhances circuit formation to synaptic transmission for mature neurons in the brain. However, reduced BDNF expression and single nucleotide polymorphisms (SNP) are reported to be associated with functional deficit and disease development in the brain, suggesting that BDNF is a crucial molecule for brain health. Interestingly, BDNF is also expressed in the hypothalamus in appetite and energy metabolism. Previous reports demonstrated that BDNF knockout mice exhibited overeating and obesity phenotypes remarkably. Therefore, we could raise a hypothesis that the loss of function of BDNF may be associated with metabolic syndrome and peripheral diseases. In this review, we describe our recent finding that BDNF knockout mice develop metabolic dysfunction-associated steatohepatitis and recent reports demonstrating the role of one of the BDNF receptors, TrkB-T1, in some peripheral organ functions and diseases, and would provide an insight into the role of BDNF beyond the brain.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom14040444