Functionalized Antimicrobial Nanofibers: Design Criteria and Recent Advances

The rise of antibiotic resistance has become a major threat to human health and it is spreading globally. It can cause common infectious diseases to be difficult to treat and leads to higher medical costs and increased mortality. Hence, multifunctional polymeric nanofibers with distinctive structure...

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Bibliographic Details
Published in:Journal of functional biomaterials 2021-10, Vol.12 (4), p.59
Main Authors: Hamdan, Nazirah, Yamin, Alisa, Hamid, Shafida Abd, Khodir, Wan Khartini Wan Abdul, Guarino, Vincenzo
Format: Article
Language:English
Subjects:
Antibiotic resistance
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
antimicrobial resistance
Bacteria
Bacterial diseases
Bacterial infections
Biofilms
Cell adhesion & migration
Design criteria
Drug delivery systems
Drug resistance
electrospinning
Extracellular matrix
Health risks
Infectious diseases
Mechanical properties
Nanofibers
Nanostructured materials
non-antibiotic treatments
Physiochemistry
Polymers
Polyvinyl alcohol
Review
Staphylococcus infections
surface functionalization
Topography
Viscosity
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Summary:The rise of antibiotic resistance has become a major threat to human health and it is spreading globally. It can cause common infectious diseases to be difficult to treat and leads to higher medical costs and increased mortality. Hence, multifunctional polymeric nanofibers with distinctive structures and unique physiochemical properties have emerged as a neo-tool to target biofilm and overcome deadly bacterial infections. This review emphasizes electrospun nanofibers' design criteria and properties that can be utilized to enhance their therapeutic activity for antimicrobial therapy. Also, we present recent progress in designing the surface functionalization of antimicrobial nanofibers with non-antibiotic agents for effective antibacterial therapy. Lastly, we discuss the future trends and remaining challenges for polymeric nanofibers.
ISSN:2079-4983
2079-4983
DOI:10.3390/jfb12040059