Mathematical Modeling of Biosensors Based on an Array of Enzyme Microreactors

This paper presents a two-dimensional-in-space mathematical model ofbiosensors based on an array of enzyme microreactors immobilised on a single electrode.The modeling system acts under amperometric conditions. The microreactors were modeledby particles and by strips. The model is based on the diffu...

Full description

Saved in:
Bibliographic Details
Published in:Sensors (Basel, Switzerland) Switzerland), 2006-04, Vol.6 (4), p.453-465
Main Authors: Baronas, Romas, Ivanauskas, Feliksas, Kulys, Juozas
Format: Article
Language:English
Subjects:
Arrays
biosensor
Biosensors
Computer simulation
Electrodes
Enzymes
Full Research Paper
Geometry
Informatics
Investigations
Mathematical models
microreactor
modeling
Reaction-diffusion
Sensors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This paper presents a two-dimensional-in-space mathematical model ofbiosensors based on an array of enzyme microreactors immobilised on a single electrode.The modeling system acts under amperometric conditions. The microreactors were modeledby particles and by strips. The model is based on the diffusion equations containing a non-linear term related to the Michaelis-Menten kinetics of the enzymatic reaction. The modelinvolves three regions: an array of enzyme microreactors where enzyme reaction as well asmass transport by diffusion takes place, a diffusion limiting region where only the diffusiontakes place, and a convective region, where the analyte concentration is maintained constant.Using computer simulation, the influence of the geometry of the microreactors and of thediffusion region on the biosensor response was investigated. The digital simulation wascarried out using the finite difference technique.
ISSN:1424-8220
1424-8220
DOI:10.3390/s6040453