Platelet count can predict the grade of esophageal varices in cirrhotic patients: a cross-sectional study [version 1; peer review: 1 approved, 1 approved with reservations]

• Published in: F1000 research 2021, Vol.10, p.101
• Main Authors: Afsar, Anum, Nadeem, Muhammad, Shah, Syed Asim Ali, Hussain, Huma, Rani, Aysha, Ghaffar, Sadaf
• Format: Article
• Language: English
• Subjects: Aged; Cirrhosis; Cross-Sectional Studies; eng; Esophageal and Gastric Varices - etiology; Gastrointestinal Hemorrhage - etiology; Humans; Liver Cirrhosis - complications; Male; Middle Aged; Platelet; Platelet Count; Varices
• ISSN: 2046-1402; 2046-1402
• DOI: 10.12688/f1000research.28005.1

Background: Bleeding from esophageal varices is a life-threatening complication in cirrhosis. Screening endoscopy is recommended in cirrhotic patients to identify patients at risk of variceal hemorrhage, but this is an invasive procedure and has limitations. Therefore, thrombocytopenia has been proposed to predict the existence and grade of esophageal varices. The aim of the current study was to determine a correlation between platelet count and grades of esophageal varices in patients with liver cirrhosis. Methods: This cross-sectional study was conducted at the POF Hospital, Wah Cantt from 1 st October, 2017 to 30 th May, 2018. Newly diagnosed cases of cirrhosis having varices of any grade on endoscopy were included. Endoscopic findings of patients were standardized using Paquet grading system. On the basis of platelet count, patients were divided into four subgroups. Platelet count groups were correlated with grading of esophageal varices using Spearman rank correlations. Chi Square test was used to see association between the platelet count and grade of esophageal varices. Results: 110 patients were included in the study, 55.5% (n=61) were male. Mean age of the patients was 59.89±9.01 years. Platelet count was 150,000/uL in 25.5% patients. Grade I esophageal varices were found in 23.6% of patients, whereas grade II, III and IV were found in 24.5%, 33.6% and 18.2% of patients, respectively. Mean platelet count was 213884.62/mm 3 in patients with grade I varices, whereas it was 119518.52/mm 3, 58386.49/mm 3 and 21600.00/mm 3 in patients with grade II, III and IV varices, respectively (p=