Role of Glycolytic and Glutamine Metabolism Reprogramming on the Proliferation, Invasion, and Apoptosis Resistance through Modulation of Signaling Pathways in Glioblastoma

Glioma cells exhibit genetic and metabolic alterations that affect the deregulation of several cellular signal transduction pathways, including those related to glucose metabolism. Moreover, oncogenic signaling pathways induce the expression of metabolic genes, increasing the metabolic enzyme activi...

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Published in:International journal of molecular sciences 2023-12, Vol.24 (24), p.17633
Main Authors: Trejo-Solis, Cristina, Silva-Adaya, Daniela, Serrano-García, Norma, Magaña-Maldonado, Roxana, Jimenez-Farfan, Dolores, Ferreira-Guerrero, Elizabeth, Cruz-Salgado, Arturo, Castillo-Rodriguez, Rosa Angelica
Format: Article
Language:English
Subjects:
Amino acids
Angiogenesis
Apoptosis
Autophagy
Brain cancer
Carbohydrates
Cell growth
Cyclin-dependent kinases
Dehydrogenases
Enzymes
Epigenetics
Glioma
Glucose
glutamine
Growth factors
Hypoxia
Kinases
Medical prognosis
Metabolism
Metabolites
Mutation
oncogenic pathways
Proteins
Tumors
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Summary:Glioma cells exhibit genetic and metabolic alterations that affect the deregulation of several cellular signal transduction pathways, including those related to glucose metabolism. Moreover, oncogenic signaling pathways induce the expression of metabolic genes, increasing the metabolic enzyme activities and thus the critical biosynthetic pathways to generate nucleotides, amino acids, and fatty acids, which provide energy and metabolic intermediates that are essential to accomplish the biosynthetic needs of glioma cells. In this review, we aim to explore how dysregulated metabolic enzymes and their metabolites from primary metabolism pathways in glioblastoma (GBM) such as glycolysis and glutaminolysis modulate anabolic and catabolic metabolic pathways as well as pro-oncogenic signaling and contribute to the formation, survival, growth, and malignancy of glioma cells. Also, we discuss promising therapeutic strategies by targeting the key players in metabolic regulation. Therefore, the knowledge of metabolic reprogramming is necessary to fully understand the biology of malignant gliomas to improve patient survival significantly.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms242417633