The Remarkable Plasticity of Macrophages: A Chance to Fight Cancer

It is well established that tumor-associated macrophages (TAM) found in most advanced tumors have a pro-tumoral role. In this context, TAM limit the activity of tumor-infiltrating lymphocytes (TIL), and a number of mechanisms have been described including a trapping in the stroma, impeding TIL to re...

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Bibliographic Details
Published in:Frontiers in immunology 2019-07, Vol.10, p.1563-1563
Main Authors: Bercovici, Nadège, Guérin, Marion V, Trautmann, Alain, Donnadieu, Emmanuel
Format: Article
Language:English
Subjects:
cancer
Immunology
immunotherapy
inflammation
Life Sciences
macrophages
migration
T cells
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Summary:It is well established that tumor-associated macrophages (TAM) found in most advanced tumors have a pro-tumoral role. In this context, TAM limit the activity of tumor-infiltrating lymphocytes (TIL), and a number of mechanisms have been described including a trapping in the stroma, impeding TIL to reach malignant cells. Based on these results, a number of therapeutic approaches have been designed to deplete TAM. However, during tumor regression induced by immunotherapeutic treatments, recent studies revealed that TAM can switch from pro-tumoral to anti-tumoral and actively cooperate with TIL. Here, we will review the two faces of TAM in their interaction with TIL. We will summarize how they can inhibit T cell activities in growing tumors, and how they may also, together with T cells, successfully contribute to tumor eradication after an appropriate stimulation. Finally, we will discuss current promising therapies combining TAM reprogramming with T cell-based immunotherapy.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2019.01563