Effects of Neurological Disorders on Bone Health

Neurological diseases, particularly in the context of aging, have serious impacts on quality of life and can negatively affect bone health. The brain-bone axis is critically important for skeletal metabolism, sensory innervation, and endocrine cross-talk between these organs. This review discusses c...

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Bibliographic Details
Published in:Frontiers in psychology 2020-11, Vol.11, p.612366
Main Authors: Kelly, Ryan R, Sidles, Sara J, LaRue, Amanda C
Format: Article
Language:English
Subjects:
bone
depression
disease
mental health
Neurology
osteoporosis
Psychology
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Summary:Neurological diseases, particularly in the context of aging, have serious impacts on quality of life and can negatively affect bone health. The brain-bone axis is critically important for skeletal metabolism, sensory innervation, and endocrine cross-talk between these organs. This review discusses current evidence for the cellular and molecular mechanisms by which various neurological disease categories, including autoimmune, developmental, dementia-related, movement, neuromuscular, stroke, trauma, and psychological, impart changes in bone homeostasis and mass, as well as fracture risk. Likewise, how bone may affect neurological function is discussed. Gaining a better understanding of brain-bone interactions, particularly in patients with underlying neurological disorders, may lead to development of novel therapies and discovery of shared risk factors, as well as highlight the need for broad, whole-health clinical approaches toward treatment.
ISSN:1664-1078
1664-1078
DOI:10.3389/fpsyg.2020.612366