Antiprotozoal action of synthetic cinnamic acid analogs

Leishmaniasis, Chagas disease, and malaria cause morbidity globally. The drugs currently used for treatment have limitations. Activity of cinnamic acid analogs against Leishmania spp., Trypanosoma cruzi, and Plasmodium falciparum was evaluated in the interest of identifying new antiprotozoal compoun...

Full description

Saved in:
Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical 2018-11, Vol.51 (6), p.849-853
Main Authors: Santos, Ana Paula de Azevedo Dos, Fialho, Saara Nery, Medeiros, Daniel Sol Sol de, Garay, Ana Fidelina Gómez, Diaz, Jorge Alfonso Ruiz, Gómez, Maria Celeste Vega, Teles, Carolina Bioni Garcia, Calderon, Leonardo de Azevedo
Format: Article
Language:English
Subjects:
Analogs
Antiprotozoal activity
Antiprotozoal agents
Antiprotozoal Agents - chemistry
Antiprotozoal Agents - pharmacology
Bioactivity
Chagas disease
Cinnamates - chemistry
Cinnamates - pharmacology
Cinnamic acid
Cytotoxicity
Identification methods
In vitro methods and tests
Leishmania - drug effects
Leishmaniasis
Malaria
Morbidity
Parasitic Sensitivity Tests
Plasmodium falciparum
Plasmodium falciparum - drug effects
Protozoa
Synthetic
Tropical diseases
TROPICAL MEDICINE
Trypanosoma cruzi - drug effects
Vector-borne diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Leishmaniasis, Chagas disease, and malaria cause morbidity globally. The drugs currently used for treatment have limitations. Activity of cinnamic acid analogs against Leishmania spp., Trypanosoma cruzi, and Plasmodium falciparum was evaluated in the interest of identifying new antiprotozoal compounds. In vitro effects of analogs against L. braziliensis, L. infantum chagasi, T. cruzi, and P. falciparum, and hemolytic and cytotoxic activities on NCTC 929 were determined. Three analogs showed leishmanicidal and tripanocidal activity. No antiplasmodial, hemolytic, or cytotoxic activity was observed. Antiprotozoal activity of analogs against L. infantum braziliensis, L. infantum chagasi, and T. cruzi was demonstrated.
ISSN:0037-8682
1678-9849
1678-9849
DOI:10.1590/0037-8682-0499-2017