Nitrate reduction capacity of the oral microbiota is impaired in periodontitis: potential implications for systemic nitric oxide availability

The reduction of nitrate to nitrite by the oral microbiota has been proposed to be important for oral health and results in nitric oxide formation that can improve cardiometabolic conditions. Studies of bacterial composition in subgingival plaque suggest that nitrate-reducing bacteria are associated...

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Bibliographic Details
Published in:International journal of oral science 2024-01, Vol.16 (1), p.1-10, Article 1
Main Authors: Rosier, Bob T., Johnston, William, Carda-Diéguez, Miguel, Simpson, Annabel, Cabello-Yeves, Elena, Piela, Krystyna, Reilly, Robert, Artacho, Alejandro, Easton, Chris, Burleigh, Mia, Culshaw, Shauna, Mira, Alex
Format: Article
Language:English
Subjects:
631/326/2565/2134
631/443
692/699/3017
Bacteria
Denitrifying bacteria
Dental Plaque - microbiology
Dentistry
Gingiva
Gum disease
Humans
Medicine
Microbiota
Microbiota - genetics
Microorganisms
Nitrate reduction
Nitrates
Nitric Oxide
Nitrites
Oral and Maxillofacial Surgery
Orthopedics
Periodontitis
Periodontitis - microbiology
RNA, Ribosomal, 16S - genetics
rRNA 16S
Saliva
Saliva - microbiology
Surgical Orthopedics
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Summary:The reduction of nitrate to nitrite by the oral microbiota has been proposed to be important for oral health and results in nitric oxide formation that can improve cardiometabolic conditions. Studies of bacterial composition in subgingival plaque suggest that nitrate-reducing bacteria are associated with periodontal health, but the impact of periodontitis on nitrate-reducing capacity (NRC) and, therefore, nitric oxide availability has not been evaluated. The current study aimed to evaluate how periodontitis affects the NRC of the oral microbiota. First, 16S rRNA sequencing data from five different countries were analyzed, revealing that nitrate-reducing bacteria were significantly lower in subgingival plaque of periodontitis patients compared with healthy individuals ( P  
ISSN:2049-3169
1674-2818
2049-3169
DOI:10.1038/s41368-023-00266-9