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High prevalence and genetic diversity of Treponema paraluisleporidarum isolates in European lagomorphs
Syphilis is an ancient disease of humans and lagomorphs caused by two distinct but genetically closely related bacteria (>98% sequence identity based on the whole genome) of the genus . While human syphilis is well studied, little is known about the disease in the lagomorph host. Yet, comparative...
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| Published in: | Microbiology spectrum 2024-01, Vol.12 (1), p.e0177423-e0177423 |
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| creator | Knauf, Sascha Hisgen, Linda Ågren, Erik O Barlow, Alexander M Faehndrich, Marcus Voigt, Ulrich Fischer, Luisa Grillová, Linda Hallmaier-Wacker, Luisa K Kik, Marja J L Klink, Jana C Křenová, Jitka Lavazza, Antonio Lüert, Simone Nováková, Markéta Čejková, Darina Pacioni, Carlo Trogu, Tiziana Šmajs, David Roos, Christian |
| description | Syphilis is an ancient disease of humans and lagomorphs caused by two distinct but genetically closely related bacteria (>98% sequence identity based on the whole genome) of the genus
. While human syphilis is well studied, little is known about the disease in the lagomorph host. Yet, comparative studies are needed to understand mechanisms in host-pathogen coevolution in treponematoses. Importantly,
-infected hare populations provide ample opportunity to study the syphilis-causing pathogen in a naturally infected model population without antibiotic treatment, data that cannot be obtained from syphilis infection in humans. We provide data on genetic diversity and are able to highlight various types of repetitions in one of the two hypervariable regions at the
locus that have not been described in the human syphilis-causing sister bacterium
subsp.
. |
| doi_str_mv | 10.1128/spectrum.01774-23 |
| format | article |
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. While human syphilis is well studied, little is known about the disease in the lagomorph host. Yet, comparative studies are needed to understand mechanisms in host-pathogen coevolution in treponematoses. Importantly,
-infected hare populations provide ample opportunity to study the syphilis-causing pathogen in a naturally infected model population without antibiotic treatment, data that cannot be obtained from syphilis infection in humans. We provide data on genetic diversity and are able to highlight various types of repetitions in one of the two hypervariable regions at the
locus that have not been described in the human syphilis-causing sister bacterium
subsp.
.</description><identifier>ISSN: 2165-0497</identifier><identifier>EISSN: 2165-0497</identifier><identifier>DOI: 10.1128/spectrum.01774-23</identifier><identifier>PMID: 38095473</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Animals ; Epidemiology ; European brown hare ; Genetic Variation ; Humans ; Lagomorpha ; Lepus ; Oryctolagus ; Prevalence ; rabbit ; Research Article ; spirochetes ; syphilis ; Syphilis - epidemiology ; Syphilis - microbiology ; Treponema - genetics ; Treponema pallidum</subject><ispartof>Microbiology spectrum, 2024-01, Vol.12 (1), p.e0177423-e0177423</ispartof><rights>Copyright © 2023 Knauf et al.</rights><rights>Copyright © 2023 Knauf et al. 2023 Knauf et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-a457t-b2da911387a572acb701a2568649219e9bb1e358566501adf48ae7106e21264a3</cites><orcidid>0000-0003-0190-4266 ; 0000-0002-5347-0407 ; 0000-0002-7646-3592 ; 0000-0002-6989-6330 ; 0000-0002-4176-3464 ; 0000-0002-9505-4612 ; 0000-0001-8249-4494 ; 0000-0001-5744-4946</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.asm.org/doi/pdf/10.1128/spectrum.01774-23$$EPDF$$P50$$Gasm2$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.asm.org/doi/full/10.1128/spectrum.01774-23$$EHTML$$P50$$Gasm2$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3188,27924,27925,52751,52752,52753,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38095473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Faucher, Sébastien P.</contributor><creatorcontrib>Knauf, Sascha</creatorcontrib><creatorcontrib>Hisgen, Linda</creatorcontrib><creatorcontrib>Ågren, Erik O</creatorcontrib><creatorcontrib>Barlow, Alexander M</creatorcontrib><creatorcontrib>Faehndrich, Marcus</creatorcontrib><creatorcontrib>Voigt, Ulrich</creatorcontrib><creatorcontrib>Fischer, Luisa</creatorcontrib><creatorcontrib>Grillová, Linda</creatorcontrib><creatorcontrib>Hallmaier-Wacker, Luisa K</creatorcontrib><creatorcontrib>Kik, Marja J L</creatorcontrib><creatorcontrib>Klink, Jana C</creatorcontrib><creatorcontrib>Křenová, Jitka</creatorcontrib><creatorcontrib>Lavazza, Antonio</creatorcontrib><creatorcontrib>Lüert, Simone</creatorcontrib><creatorcontrib>Nováková, Markéta</creatorcontrib><creatorcontrib>Čejková, Darina</creatorcontrib><creatorcontrib>Pacioni, Carlo</creatorcontrib><creatorcontrib>Trogu, Tiziana</creatorcontrib><creatorcontrib>Šmajs, David</creatorcontrib><creatorcontrib>Roos, Christian</creatorcontrib><title>High prevalence and genetic diversity of Treponema paraluisleporidarum isolates in European lagomorphs</title><title>Microbiology spectrum</title><addtitle>Spectrum</addtitle><addtitle>Microbiol Spectr</addtitle><description>Syphilis is an ancient disease of humans and lagomorphs caused by two distinct but genetically closely related bacteria (>98% sequence identity based on the whole genome) of the genus
. While human syphilis is well studied, little is known about the disease in the lagomorph host. Yet, comparative studies are needed to understand mechanisms in host-pathogen coevolution in treponematoses. Importantly,
-infected hare populations provide ample opportunity to study the syphilis-causing pathogen in a naturally infected model population without antibiotic treatment, data that cannot be obtained from syphilis infection in humans. We provide data on genetic diversity and are able to highlight various types of repetitions in one of the two hypervariable regions at the
locus that have not been described in the human syphilis-causing sister bacterium
subsp.
.</description><subject>Animals</subject><subject>Epidemiology</subject><subject>European brown hare</subject><subject>Genetic Variation</subject><subject>Humans</subject><subject>Lagomorpha</subject><subject>Lepus</subject><subject>Oryctolagus</subject><subject>Prevalence</subject><subject>rabbit</subject><subject>Research Article</subject><subject>spirochetes</subject><subject>syphilis</subject><subject>Syphilis - epidemiology</subject><subject>Syphilis - microbiology</subject><subject>Treponema - genetics</subject><subject>Treponema pallidum</subject><issn>2165-0497</issn><issn>2165-0497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9kstq3DAUhkVpacI0D9BN0bKbmepq2atSQtoEAt2ka3FsHXs02JIr2QN5-yqZJCSbLoTEuXxHv34R8pmzHeei_pZn7Ja0TjvGjVFbId-Rc8ErvWWqMe9fnc_IRc4HxhjnTAstPpIzWbNGKyPPSX_thz2dEx5hxNAhheDogAEX31Hnj5iyX-5p7OldwjkGnIDOkGBcfR5LIHkH5RLU5zjCgpn6QK_WFGeEQEcY4hTTvM-fyIcexowXT_uG_Pl5dXd5vb39_evm8sftFpQ2y7YVDhrOZW1AGwFdaxgHoau6Uo3gDTZty1HqWleVLhnXqxrQcFah4KJSIDfk5sR1EQ52Tn6CdG8jePsYiGmwkIq0Ea1k4DpjdN8wpcA1UMiyYszw3gnVYmF9P7HmtZ3QdRiWovsN9G0m-L0d4tFyZmr5sDbk6xMhxb8r5sVOPnc4jhAwrtmKhommKmJUKeWn0i7FnBP2L3M4sw9-22e_7aPfVsjSszv1QJ6EPcQ1hfK2_2348lrRy4jn7yD_ASs1uZ4</recordid><startdate>20240111</startdate><enddate>20240111</enddate><creator>Knauf, Sascha</creator><creator>Hisgen, Linda</creator><creator>Ågren, Erik O</creator><creator>Barlow, Alexander M</creator><creator>Faehndrich, Marcus</creator><creator>Voigt, Ulrich</creator><creator>Fischer, Luisa</creator><creator>Grillová, Linda</creator><creator>Hallmaier-Wacker, Luisa K</creator><creator>Kik, Marja J L</creator><creator>Klink, Jana C</creator><creator>Křenová, Jitka</creator><creator>Lavazza, Antonio</creator><creator>Lüert, Simone</creator><creator>Nováková, Markéta</creator><creator>Čejková, Darina</creator><creator>Pacioni, Carlo</creator><creator>Trogu, Tiziana</creator><creator>Šmajs, David</creator><creator>Roos, Christian</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-0190-4266</orcidid><orcidid>https://orcid.org/0000-0002-5347-0407</orcidid><orcidid>https://orcid.org/0000-0002-7646-3592</orcidid><orcidid>https://orcid.org/0000-0002-6989-6330</orcidid><orcidid>https://orcid.org/0000-0002-4176-3464</orcidid><orcidid>https://orcid.org/0000-0002-9505-4612</orcidid><orcidid>https://orcid.org/0000-0001-8249-4494</orcidid><orcidid>https://orcid.org/0000-0001-5744-4946</orcidid></search><sort><creationdate>20240111</creationdate><title>High prevalence and genetic diversity of Treponema paraluisleporidarum isolates in European lagomorphs</title><author>Knauf, Sascha ; 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. While human syphilis is well studied, little is known about the disease in the lagomorph host. Yet, comparative studies are needed to understand mechanisms in host-pathogen coevolution in treponematoses. Importantly,
-infected hare populations provide ample opportunity to study the syphilis-causing pathogen in a naturally infected model population without antibiotic treatment, data that cannot be obtained from syphilis infection in humans. We provide data on genetic diversity and are able to highlight various types of repetitions in one of the two hypervariable regions at the
locus that have not been described in the human syphilis-causing sister bacterium
subsp.
.</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>38095473</pmid><doi>10.1128/spectrum.01774-23</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0003-0190-4266</orcidid><orcidid>https://orcid.org/0000-0002-5347-0407</orcidid><orcidid>https://orcid.org/0000-0002-7646-3592</orcidid><orcidid>https://orcid.org/0000-0002-6989-6330</orcidid><orcidid>https://orcid.org/0000-0002-4176-3464</orcidid><orcidid>https://orcid.org/0000-0002-9505-4612</orcidid><orcidid>https://orcid.org/0000-0001-8249-4494</orcidid><orcidid>https://orcid.org/0000-0001-5744-4946</orcidid><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central Free; American Society for Microbiology Journals |
| subjects | Animals Epidemiology European brown hare Genetic Variation Humans Lagomorpha Lepus Oryctolagus Prevalence rabbit Research Article spirochetes syphilis Syphilis - epidemiology Syphilis - microbiology Treponema - genetics Treponema pallidum |
| title | High prevalence and genetic diversity of Treponema paraluisleporidarum isolates in European lagomorphs |
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