Stressful Newborn Memories: Pre-Conceptual, In Utero , and Postnatal Events

Early-life stressful experiences are critical for plasticity and development, shaping adult neuroendocrine response and future health. Stress response is mediated by the autonomous nervous system and the hypothalamic-pituitary-adrenal (HPA) axis while various environmental stimuli are encoded epigen...

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Bibliographic Details
Published in:Frontiers in psychiatry 2019-04, Vol.10, p.220-220
Main Authors: Papadopoulou, Zoe, Vlaikou, Angeliki-Maria, Theodoridou, Daniela, Markopoulos, Georgios S, Tsoni, Konstantina, Agakidou, Eleni, Drosou-Agakidou, Vasiliki, Turck, Christoph W, Filiou, Michaela D, Syrrou, Maria
Format: Article
Language:English
Subjects:
early-life stress
epigenetics
individuality
low birth weight
predisposition
Psychiatry
stress
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Summary:Early-life stressful experiences are critical for plasticity and development, shaping adult neuroendocrine response and future health. Stress response is mediated by the autonomous nervous system and the hypothalamic-pituitary-adrenal (HPA) axis while various environmental stimuli are encoded epigenetic marks. The stress response system maintains homeostasis by regulating adaptation to the environmental changes. Pre-conceptual and stressors form the fetal epigenetic profile together with the individual genetic profile, providing the background for individual stress response, vulnerability, or resilience. Postnatal and adult stressful experiences may act as the definitive switch. This review addresses the issue of how preconceptual and postnatal events, together with individual differences, shape future stress responses. Putative markers of early-life adverse effects such as prematurity and low birth weight are emphasized, and the epigenetic, mitochondrial, and genomic architecture regulation of such events are discussed.
ISSN:1664-0640
1664-0640
DOI:10.3389/fpsyt.2019.00220