Evaluation of Antibiotic Dissemination into the Environment and Untreated Animals, by Analysis of Oxytetracycline in Poultry Droppings and Litter

Oxytetracycline (OTC) is widely used in broiler chickens. During and after treatment a fraction of OTC is excreted in its original form and as its epimer, 4-epi-OTC in droppings. To address the transfer of OTC into the environment, we evaluated the dissemination of OTC and 4-epi-OTC from treated bir...

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Bibliographic Details
Published in:Animals (Basel) 2021-03, Vol.11 (3), p.853
Main Authors: Pokrant, Ekaterina, Yévenes, Karina, Trincado, Lina, Terraza, Gigliola, Galarce, Nicolás, Maddaleno, Aldo, Martín, Betty San, Lapierre, Lisette, Cornejo, Javiera
Format: Article
Language:English
Subjects:
4-epi-Oxytetracycline
Analytical chemistry
Animal health
Animal welfare
Animals
Antibiotics
Antimicrobial agents
Bacteria
Birds
broiler chicken
By products
Chickens
Controlled conditions
Drinking water
Environmental hazards
Feeds
Gastrointestinal system
Gastrointestinal tract
High-performance liquid chromatography
HPLC-MS/MS
Humidity
Liquid chromatography
Manures
Oxytetracycline
Poultry
poultry droppings
poultry litter
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Summary:Oxytetracycline (OTC) is widely used in broiler chickens. During and after treatment a fraction of OTC is excreted in its original form and as its epimer, 4-epi-OTC in droppings. To address the transfer of OTC into the environment, we evaluated the dissemination of OTC and 4-epi-OTC from treated birds to the environment and sentinels, through the simultaneous analysis of broiler droppings and litter. Male broiler chickens were bred in controlled conditions. One group was treated by orogastric tube with 80 mg kg of OTC and two groups received no treatment (sentinels). OTC+4-epi-OTC were analyzed and detected by a HPLC-MS/MS post the end of treatment. The highest concentrations of OTC+4-epi-OTC were detected in the droppings of treated birds 14-days following the end of treatment (2244.66 µg kg ), and one day following the end of treatment in the litter (22,741.68 µg kg ). Traces of OTC+4-epi-OTC were detected in the sentinels' droppings and litter (
ISSN:2076-2615
2076-2615
DOI:10.3390/ani11030853