Polygodial, the Fungitoxic Component from the Brazilian Medicinal Plant Polygonum punctatum

Polygonum punctatum (Polygonaceae) is an herb known in some regions of Brazil as "erva-de-bicho" and is used to treat intestinal disorders. The dichloromethane extract of the aerial parts of this plant showed strong activity in a bioautographic assay with the fungus Cladosporium sphaerospe...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz 2001-08, Vol.96 (6), p.831-833
Main Authors: de Almeida Alves, T M, Ribeiro, F L, Kloos, H, Zani, C L
Format: Article
Language:English
Subjects:
antifungal
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Brazil
Cladosporium - drug effects
Cladosporium sphaerospermum
medicinal plants
medicinal plants, Cladosporium sphaerospermum, antifungal, polygodial, sesquiterpene, Brazil
PARASITOLOGY
Plant Extracts - chemistry
Plant Extracts - pharmacology
polygodial
Polygonum - chemistry
Polygonum punctatum
sesquiterpene
Sesquiterpenes - chemistry
Sesquiterpenes - pharmacology
TROPICAL MEDICINE
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Summary:Polygonum punctatum (Polygonaceae) is an herb known in some regions of Brazil as "erva-de-bicho" and is used to treat intestinal disorders. The dichloromethane extract of the aerial parts of this plant showed strong activity in a bioautographic assay with the fungus Cladosporium sphaerospermum. The bioassay-guided chemical fractionation of this extract afforded the sesquiterpene dialdehyde polygodial as the active constituent. The presence of this compound with antibiotic, anti-inflammatory and anti-hyperalgesic properties in "erva-de-bicho" may account for the effects attributed by folk medicine to this plant species.
ISSN:1678-8060
0074-0276
0074-0276
1678-8060
DOI:10.1590/s0074-02762001000600016