RETRACTED ARTICLE: CircHAS2 promotes the proliferation, migration, and invasion of gastric cancer cells by regulating PPM1E mediated by hsa-miR-944

Gastric cancer (GC) is considered one of the most common gastrointestinal malignancies worldwide. Circular RNAs (circRNAs) are a new class of endogenous noncoding RNAs, which can be used as biomarkers and therapeutic targets for many tumors. However, the role and potential regulatory mechanisms of c...

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Bibliographic Details
Published in:Cell death & disease 2021-09, Vol.12 (10), p.863-12, Article 863
Main Authors: Ma, Shuo, Gu, Xinliang, Shen, Lei, Chen, Yinhao, Qian, Chen, Shen, Xianjuan, Ju, Shaoqing
Format: Article
Language:English
Subjects:
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Antibodies
Biochemistry
Biomarkers
Biomedical and Life Sciences
Cell Biology
Cell Culture
Cell proliferation
Gastric cancer
Immunology
Life Sciences
Magnesium
Mesenchyme
Metastases
Protein phosphatase
Therapeutic applications
Therapeutic targets
Tumors
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Summary:Gastric cancer (GC) is considered one of the most common gastrointestinal malignancies worldwide. Circular RNAs (circRNAs) are a new class of endogenous noncoding RNAs, which can be used as biomarkers and therapeutic targets for many tumors. However, the role and potential regulatory mechanisms of circRNAs in GC remain unclear. In this study, we demonstrated that a specific circRNA, circHAS2, was upregulated in GC tissues and cells and was positively correlated with tumor metastasis. In vitro experiments demonstrated that circHAS2 knockdown or the addition of hsa-miR-944 mimics inhibited the proliferation, migration, and invasion ability of GC cells and affected the epithelial-mesenchymal transition. In addition, hsa-miR-944 interacted with protein phosphatase, Mg 2+ /Mn 2+ -dependent 1E (PPM1E), and was found to be a target gene of circHAS2. The upregulation of PPM1E reversed the effects of circHAS2 knockout on GC cells. The circHAS2/hsa-miR-944/PPM1E axis may be involved in the progression of GC; thus, circHAS2 may be a potential biomarker and therapeutic target for GC.
ISSN:2041-4889
2041-4889
DOI:10.1038/s41419-021-04158-w