Growth promotion and antibiotic induced metabolic shifts in the chicken gut microbiome

Antimicrobial growth promoters (AGP) have played a decisive role in animal agriculture for over half a century. Despite mounting concerns about antimicrobial resistance and demand for antibiotic alternatives, a thorough understanding of how these compounds drive performance is missing. Here we inves...

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Bibliographic Details
Published in:Communications biology 2022-04, Vol.5 (1), p.293-293, Article 293
Main Authors: Plata, Germán, Baxter, Nielson T., Susanti, Dwi, Volland-Munson, Alyssa, Gangaiah, Dharanesh, Nagireddy, Akshitha, Mane, Shrinivasrao P., Balakuntla, Jayanth, Hawkins, Troy B., Kumar Mahajan, Arvind
Format: Article
Language:English
Subjects:
45/23
631/326/22/1290
631/326/2565/2134
631/326/2565/2142
631/553/2710
Animals
Anti-Bacterial Agents - pharmacology
Antibiotics
Antimicrobial agents
Antimicrobial resistance
Bacteria
Biology
Biomedical and Life Sciences
Cecum
Chickens
Drug resistance
Gastrointestinal Microbiome
Intestinal microflora
Life Sciences
Metabolism
Metabolites
Metabolomics
Microbiomes
Microbiota
Promoters
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Summary:Antimicrobial growth promoters (AGP) have played a decisive role in animal agriculture for over half a century. Despite mounting concerns about antimicrobial resistance and demand for antibiotic alternatives, a thorough understanding of how these compounds drive performance is missing. Here we investigate the functional footprint of microbial communities in the cecum of chickens fed four distinct AGP. We find relatively few taxa, metabolic or antimicrobial resistance genes similarly altered across treatments, with those changes often driven by the abundances of core microbiome members. Constraints-based modeling of 25 core bacterial genera associated increased performance with fewer metabolite demands for microbial growth, pointing to altered nitrogen utilization as a potential mechanism of narasin, the AGP with the largest performance increase in our study. Untargeted metabolomics of narasin treated birds aligned with model predictions, suggesting that the core cecum microbiome might be targeted for enhanced performance via its contribution to host-microbiota metabolic crosstalk. This study compares the functional profiles of the cecal microbiome among chickens fed four different antimicrobial growth promoters. Chickens receiving narasin exhibited the largest performance increase via apparent nitrogen recycling by the core cecal microbiome.
ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-022-03239-6