Correlations Between Working Memory Impairment and Neurometabolites of the Prefrontal Cortex in Drug-Naive Obsessive-Compulsive Disorder

• Published in: Neuropsychiatric disease and treatment 2021-01, Vol.17, p.2647-2657
• Main Authors: Yue, Jihui, Zhong, Shuming, Luo, Aimin, Lai, Shunkai, He, Tingting, Luo, Yuchong, Wang, Ying, Zhang, Yiliang, Shen, Shiyi, Huang, Hui, Wen, Shenglin, Jia, Yanbin
• Format: Article
• Language: English
• Subjects: Addictive behaviors; Alcohol; Behavior; Brain; Choline; Cognitive ability; Comorbidity; Complications and side effects; Contraindications; Creatine; Drug abuse; Drug addiction; Health aspects; Inositol; Investigations; Magnetic resonance spectroscopy; Memory; Memory, Disorders of; Mental disorders; Mental task performance; Metabolism; Metabolites; Middle schools; N-Acetylaspartate; neurometabolites; Neurosciences; Obsessive compulsive disorder; Original Research; Phonology; Prefrontal cortex; proton magnetic resonance spectroscopy; Psychological aspects; Risk factors; Short term memory; Spectrum analysis; Substance abuse treatment; working memory
• ISSN: 1176-6328; 1178-2021; 1178-2021
• DOI: 10.2147/NDT.S296488

This study aimed to investigate the mechanism of working memory (WM) impairment in drug-naive obsessive-compulsive disorder (OCD) by using neuropsychological tests and proton magnetic resonance spectroscopy ( H-MRS). A total of 55 patients with drug-naive OCD and 55 healthy controls (HCs) were recruited for this study. The working memory (WM) was evaluated using the digit span test (DST), visual space memory test (VSMT), and the 2-back task and stroop color word test (SCWT). The bilateral metabolite levels of the prefrontal cortex (PFC) were evaluated by 1H-MRS, then determined the ratios of N-acetyl aspartate (NAA), choline-containing compounds (Cho), and myo-inositol (MI) to creatine (Cr). The independent sample -test was used to analyse the differences in WM performance and neurometabolite ratios. Multivariate linear regression analysis was performed to screen the influential factors of WM, with an introduction level of 0.05 and a rejection level of 0.10. 1) Patients with OCD performed significantly worse on DST (score), VSMT (score), 2-back task (accuracy rate), SCWT (execution time) when compared with HCs. 2) NAA/Cr and Cho/Cr in the left PFC (lPFC) and MI/Cr ratios in the bilateral PFC of OCD patients were significantly lower when compared to HCs. 3) For OCD patients, the NAA/Cr ratio in the lPFC was negatively correlated with the score of DST (forwards), the Cho/Cr ratio in the lPFC was positively correlated with the accuracy rate of 2-back task, and the MI/Cr ratio in the right PFC (rPFC) was positively correlated with the score of DST (forwards) and the accuracy rate of VSMT. We also found that the compulsive symptoms showed a positive correlation with MI/Cr ratio of the rPFC. Drug-naive OCD patients have demonstrated WM impairments, including phonological loop, visual-spatial sketchpad and central executive system, and the WM impairments might be associated with hypometabolism in the PFC, especially the lPFC.