Inhibition of the PI3K-Akt-mTOR signaling pathway in T lymphocytes in patients with active tuberculosis

Highlights • We mainly study the change of PI3K-Akt-mTOR signaling pathway in T lymphocytes and Treg cells from active TB patients. • The results showed that the mTOR signaling pathway in T lymphocytes and Treg cells is inhibited in active TB patients. • The mTOR pathway is inhibited in active TB pa...

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Bibliographic Details
Published in:International journal of infectious diseases 2017-06, Vol.59 (C), p.110-117
Main Authors: Zhang, XueXuan, Huang, TengYi, Wu, Ying, Peng, WenGuang, Xie, HanBin, Pan, MeiChen, Zhou, HuanBin, Cai, BoZhi, Wu, YingE
Format: Article
Language:English
Subjects:
Adult
Cytokines - metabolism
Female
Flow Cytometry
FoxP3+Treg cells
Humans
Infectious Disease
Interleukin-10 - metabolism
Male
Mycobacterium tuberculosis
Phosphatidylinositol 3-Kinases - metabolism
PI3K-Akt-mTOR pathway
PTEN Phosphohydrolase - metabolism
Pulmonary/Respiratory
Signal Transduction
T lymphocytes
T-Lymphocytes, Regulatory - metabolism
TOR Serine-Threonine Kinases - metabolism
Tuberculosis, Pulmonary - immunology
Tuberculosis, Pulmonary - metabolism
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Summary:Highlights • We mainly study the change of PI3K-Akt-mTOR signaling pathway in T lymphocytes and Treg cells from active TB patients. • The results showed that the mTOR signaling pathway in T lymphocytes and Treg cells is inhibited in active TB patients. • The mTOR pathway is inhibited in active TB patients, which could explain why FoxP3 expanded in patients in partly.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2017.04.004