Biomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis: “Always‐On” and “Turn‐On” Probes

Photoacoustic (PA) imaging is a nonionizing, noninvasive imaging technique that combines optical and ultrasonic imaging modalities to provide images with excellent contrast, spatial resolution, and penetration depth. Exogenous PA contrast agents are created to increase the sensitivity and specificit...

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Bibliographic Details
Published in:Advanced science 2022-09, Vol.9 (25), p.e2202384-n/a
Main Authors: Zeng, Yun, Dou, Taotao, Ma, Lei, Ma, Jingwen
Format: Article
Language:English
Subjects:
biomedical imaging
Brain cancer
Chemotherapy
Contrast agents
Contrast Media
diagnosis
Disease
Gold
Hemoglobin
Lipids
Medical diagnosis
Nanomaterials
nanoparticles
photoacoustic imaging
Photoacoustic Techniques - methods
probes
Review
Reviews
Spectrum Analysis
Tumors
Ultrasonic imaging
Ultrasonography
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Description
Summary:Photoacoustic (PA) imaging is a nonionizing, noninvasive imaging technique that combines optical and ultrasonic imaging modalities to provide images with excellent contrast, spatial resolution, and penetration depth. Exogenous PA contrast agents are created to increase the sensitivity and specificity of PA imaging and to offer diagnostic information for illnesses. The existing PA contrast agents are categorized into two groups in this review: “always‐on” and “turn‐on,” based on their ability to be triggered by target molecules. The present state of these probes, their merits and limitations, and their future development, is explored. Photoacoustic imaging is a nonionizing, noninvasive imaging technique that combines optical and ultrasonic imaging modalities to provide images with excellent contrast, spatial resolution, and penetration depth. Exogenous photoacoustic contrast agents are created to increase its sensitivity and specificity to offer diagnostic information. The present state of these probes, their merits and limitations, and their future development is explored.
ISSN:2198-3844
2198-3844
DOI:10.1002/advs.202202384