An Increasing Prominent Disease of Klebsiella pneumoniae Liver Abscess : Etiology, Diagnosis, and Treatment

Background. During the past two decades, Klebsiella pneumoniae (K. pneumoniae) had surpassed Escherichia coli (E. coli) as the predominant isolate from patients with pyogenic liver abscess (PLA) in Asian countries, the United States, and Europe, and it tended to spread globally. Since the clinical s...

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Bibliographic Details
Published in:Gastroenterology research and practice 2013-01, Vol.2013 (2013), p.1-12
Main Authors: Liu, Yun, Jiang, Wei, Wang, Ji-yao
Format: Article
Language:English
Subjects:
Antibiotics
Care and treatment
Causes of
Diabetes
Diagnosis
E coli
Epidemiology
Health aspects
Infections
Infectious diseases
Klebsiella
Liver
Liver diseases
Metastasis
Mortality
Pneumonia
Review
Surgery
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Summary:Background. During the past two decades, Klebsiella pneumoniae (K. pneumoniae) had surpassed Escherichia coli (E. coli) as the predominant isolate from patients with pyogenic liver abscess (PLA) in Asian countries, the United States, and Europe, and it tended to spread globally. Since the clinical symptom is atypical, the accurate and effective diagnosis and treatment of K. pneumoniae liver abscesses (KLAs) are very necessary. Methods. Here, we have comprehensively clarified the epidemiology and pathogenesis of KLA, put emphases on the clinical presentations especially the characteristic radiographic findings of KLA, and thoroughly elucidated the most effective antibiotic strategy of KLA. Results. K1 serotype is strongly associated with KLA especially in diabetic patients. Computed tomography (CT) and ultrasound (US) were two main diagnostic methods of KLA in the past. Most of KLAs have solitary, septal lobular abscesses in the right lobe of liver, and they are mainly monomicrobial. Broad-spectrum antibiotics combined with the US-guided percutaneous drainage of liver abscesses can increase their survival rates, but surgical intervention still has its irreplaceable position. Conclusion. The imaging features contribute to the early diagnosis, and the percutaneous intervention combined with an aminoglycoside plus either an extended-spectrum betalactam or a second- or third-generation cephalosporin is a timely and effective treatment of KLA.
ISSN:1687-6121
1687-630X
DOI:10.1155/2013/258514