Effects of Folic Acid Supplementation on Oxidative Stress Markers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(1) Background: This systematic review and meta-analysis aimed to assess the effects of folic acid supplementation on oxidative stress markers. (2) Methods: Online database including PubMed, Scopus, Web of Science, and Cochrane were searched up to January 2021, to retrieve randomized controlled tria...

Full description

Saved in:
Bibliographic Details
Published in:Antioxidants 2021-05, Vol.10 (6), p.871
Main Authors: Asbaghi, Omid, Ghanavati, Matin, Ashtary-Larky, Damoon, Bagheri, Reza, Rezaei Kelishadi, Mahnaz, Nazarian, Behzad, Nordvall, Michael, Wong, Alexei, Dutheil, Frédéric, Suzuki, Katsuhiko, Alavi Naeini, Amirmansour
Format: Article
Language:English
Subjects:
Antioxidants
Bias
Biomarkers
Clinical trials
Diabetes
folate
Folic acid
Glutathione
Human health and pathology
Intervention
Life Sciences
Malondialdehyde
Meta-analysis
Nitric oxide
Oxidative stress
Review
Santé publique et épidémiologie
Standard deviation
supplementation
Supplements
Systematic review
Vitamin B
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:(1) Background: This systematic review and meta-analysis aimed to assess the effects of folic acid supplementation on oxidative stress markers. (2) Methods: Online database including PubMed, Scopus, Web of Science, and Cochrane were searched up to January 2021, to retrieve randomized controlled trials (RCTs) which examined the effect of folic acid supplementation on markers of oxidative stress. Meta-analyses were carried out using a random-effects model. I2 index was used to evaluate the heterogeneity of RCTs. (3) Results: Among the initial 2322 studies that were identified from electronic databases search, 13 studies involving 1013 participants were eligible. Pooled effect size from 13 studies indicated that folic acid supplementation elicits a significant rise in serum concentrations of glutathione (GSH) (WMD: 219.01 umol/L, 95% CI 59.30 to 378.71, p = 0.007) and total antioxidant capacity (TAC) (WMD: 91.70 umol/L, 95% CI 40.52 to 142.88, p < 0.001) but has no effect on serum concentrations of nitric oxide (NO) (WMD: 2.61 umol/L, 95% CI −3.48 to 8.72, p = 0.400). In addition, folic acid supplementation significantly reduced serum concentrations of malondialdehyde (MDA) (WMD: −0.13 umol/L, 95% CI −0.24 to −0.02, p = 0.020). (4) Conclusions: This meta-analysis study suggests that folic acid supplementation may significantly improve markers within the antioxidative defense system by increasing serum concentrations of GSH and TAC and decreasing serum concentrations of MDA.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox10060871