The effect of subminimal inhibitory concentrations of penicillin on growth rate and haemolysin activity of group G Streptococcus

The influence of the subminimal inhibitory concentrations (1/3 and 1/4 of the MIC) of penicillin on growth rate and on haemolysin production of a strain of group G Streptococcus was studied. It was shown that 1/3 of the MIC almost completely inhibited the bacterial growth, but it was not able to inh...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz 1993-09, Vol.88 (3), p.431-434
Main Authors: Vieira, V V, Barrucand, L, Castro, A C
Format: Article
Language:English
Subjects:
group G Streptococcus
haemolysin
Hemolysin Proteins - metabolism
Microbial Sensitivity Tests
PARASITOLOGY
penicillin
Penicillins - administration & dosage
Penicillins - pharmacology
Streptococcus
Streptococcus - growth & development
Streptococcus - metabolism
Streptococcus - physiology
subminimal inhibitory concentrations of antibiotics
TROPICAL MEDICINE
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Summary:The influence of the subminimal inhibitory concentrations (1/3 and 1/4 of the MIC) of penicillin on growth rate and on haemolysin production of a strain of group G Streptococcus was studied. It was shown that 1/3 of the MIC almost completely inhibited the bacterial growth, but it was not able to inhibit haemolysin activity in the culture supernate. The generation time of bacteria grown in 1/4 of the MIC was approximately twice longer than that of the control culture. In all cultures, the haemolysin, after being produced (or liberated), reached a peak and decreased to low levels, which could suggest that group G Streptococcus produces some end products of metabolism that are able to inhibit haemolysin activity.
ISSN:0074-0276
1678-8060
0074-0276
1678-8060
DOI:10.1590/S0074-02761993000300013