Expression of heat shock protein 70 in oral epithelial dysplasia and oral squamous cell carcinoma: An immunohistochemical study

Introduction: Heat shock proteins are biomarkers regulating the degree of differention and aggressiveness in oral carcinogenesis. The study was carried out to evaluate the expression of HSP 70 in histological grades of epithelial dysplasia and oral squamous cell carcinoma using immunohistochemistry....

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Published in:Contemporary clinical dentistry 2019-04, Vol.10 (2), p.185-190
Main Authors: Priyanka, K, Majumdar, Sumit, Kotina, Sreekanth, Uppala, Divya, Balla, Hyandavi
Format: Article
Language:English
Subjects:
Biological markers
Biomarkers
Biopsy
Cancer
Carcinogenesis
Carcinoma
Development and progression
Dysplasia
Heat shock proteins
heat shock proteins 70
Hsp70 protein
Immunohistochemistry
Leukokeratosis
Life sciences
Metastasis
Mucosa
Oral cancer
Oral squamous cell carcinoma
Original
Proteins
Squamous cell carcinoma
Statistical analysis
Studies
tumor node and metastasis staging
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creator Priyanka, K
Majumdar, Sumit
Kotina, Sreekanth
Uppala, Divya
Balla, Hyandavi
description Introduction: Heat shock proteins are biomarkers regulating the degree of differention and aggressiveness in oral carcinogenesis. The study was carried out to evaluate the expression of HSP 70 in histological grades of epithelial dysplasia and oral squamous cell carcinoma using immunohistochemistry. Methodology: A sample of 40, which included 10 (Normal), 15 (epithelial dysplasia) and 15 (oral squamous cell carcinoma) were selected. The biopsy samples were stained using H and E staining and HSP 70 IHC. Results: There was a statistical significant difference in expression of HSP 70 between normal oral mucosal tissue, leukoplakia and OSCC. Discussion and Conclusion: This study concludes the critical role of HSP70 as an oncogene in the development of oral cancer. HSP70 inhibition is, therefore a promising therapeutic approach for cancer treatment.
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subjects Biological markers
Biomarkers
Biopsy
Cancer
Carcinogenesis
Carcinoma
Development and progression
Dysplasia
Heat shock proteins
heat shock proteins 70
Hsp70 protein
Immunohistochemistry
Leukokeratosis
Life sciences
Metastasis
Mucosa
Oral cancer
Oral squamous cell carcinoma
Original
Proteins
Squamous cell carcinoma
Statistical analysis
Studies
tumor node and metastasis staging
title Expression of heat shock protein 70 in oral epithelial dysplasia and oral squamous cell carcinoma: An immunohistochemical study
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