Association of midlife body-weight variability and cycles with earlier dementia onset: a nationwide cohort study

Given the rising awareness of health-related lifestyle modifications, the impact of changes in body weight (BW) on cognitive function and dementia generates significant concern. This study aimed to investigate the association between BW changes and dementia in a middle-aged Korean population. A retr...

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Bibliographic Details
Published in:Alzheimer's research & therapy 2024-04, Vol.16 (1), p.91-9, Article 91
Main Authors: Park, Yujin, Kim, Su Hwan, Ryu, Jiwon, Yoon, Hyung-Jin
Format: Article
Language:English
Subjects:
Adult
Age of Onset
Aged
Analysis
Body weight
Body Weight - physiology
Body weight change
Cohort Studies
Dementia
Dementia - epidemiology
Diagnosis
Early dementia risk
Female
Humans
Longitudinal Studies
Male
Mid-life body weight change
Middle Aged
National health insurance
Physical fitness
Psychological aspects
Republic of Korea - epidemiology
Retrospective Studies
Risk Factors
Type 2 diabetes
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Summary:Given the rising awareness of health-related lifestyle modifications, the impact of changes in body weight (BW) on cognitive function and dementia generates significant concern. This study aimed to investigate the association between BW changes and dementia in a middle-aged Korean population. A retrospective, population-based longitudinal study was conducted utilizing data from the National Health Insurance Service (NHIS) database. Participants aged 40 years or older in 2011 who underwent at least five health checkups between 2002 and 2011 were followed-up for dementia until 2020. A total of 3,635,988 dementia-free Korean aged 
ISSN:1758-9193
1758-9193
DOI:10.1186/s13195-024-01460-5