Clinical treatment procedure and experience of six gene-edited pig-rhesus monkey heterotopic heart xenotransplantation

[...]the recipient survival rate and quality of life are affected by major obstacles, including immune rejection, complement and coagulation dysfunction, and infection. [...]the coagulation status, such as thromboelastography parameters and coagulation factors of the recipient, should be fully under...

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Bibliographic Details
Published in:Chinese medical journal 2024-04, Vol.137 (8), p.997-999
Main Authors: Zhang, Bing, Ji, Pengfei, Peng, Langang, Zhai, Mengen, Tang, Jiayou, Zhao, Lin, Jin, Yan, Xu, Baoling, Lyu, Xiangni, Lu, Linhe, Zhou, Yenong, Jin, Zhenxiao, Duan, Weixun, Yang, Xiuling, Yi, Wei, Liu, Jincheng
Format: Article
Language:English
Subjects:
Abdomen
Animals
Anticoagulants
Drugs
Female
Gene Editing - methods
Heart failure
Heart Transplantation - methods
Heart transplants
Hogs
Humans
Immunoglobulins
Infections
Laboratory animals
Macaca mulatta
Male
Medical treatment
Monkeys & apes
Surgery
Survival analysis
Swine
Thrombosis
Transplantation, Heterologous - methods
Ultrasonic imaging
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Summary:[...]the recipient survival rate and quality of life are affected by major obstacles, including immune rejection, complement and coagulation dysfunction, and infection. [...]the coagulation status, such as thromboelastography parameters and coagulation factors of the recipient, should be fully understood in the early postoperative period to avoid hemorrhage. [...]the survival time of the recipient in this study is relatively advanced in China; however, the cause of death was still coagulation disorder. In our future study, we intend to adjust the gene-editing scheme to modify the key coagulation mechanism of regulatory target genes such as vWF and TFPI1. [...]overcoming the coagulation disorders of xenografts, maintaining the donor heart function, prolonging the survival time of the recipient as much as possible, and accumulating a research basis for the successful clinical application of gene-edited pig-human heart xenografts will be possible.
ISSN:0366-6999
2542-5641
DOI:10.1097/CM9.0000000000003030