Improved sensitivity of microperimetric outcomes for clinical studies in age-related macular degeneration

To investigate sensitive outcome measures based exclusively on abnormal points in microperimetry testing of eyes with intermediate age-related macular degeneration (iAMD). 25 eyes of 25 subjects with iAMD had undergone 2 successive tests of mesopic microperimetry with the Macular Integrity Assessmen...

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Bibliographic Details
Published in:Scientific reports 2021-02, Vol.11 (1), p.4764-4764, Article 4764
Main Authors: Barkana, Yaniv, Pondorfer, Susanne G., Schmitz-Valckenberg, Steffen, Russ, Hermann, Finger, Robert P.
Format: Article
Language:English
Subjects:
692/308/2779
692/308/409
Age
Aged
Aged, 80 and over
Clinical trials
Clinical Trials as Topic
Cross-Sectional Studies
Diagnostic Techniques, Ophthalmological
Female
Humanities and Social Sciences
Humans
Macula Lutea - pathology
Macular degeneration
Macular Degeneration - diagnosis
Male
Middle Aged
multidisciplinary
Retrospective Studies
Science
Science (multidisciplinary)
Threshold limits
Visual Acuity
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Summary:To investigate sensitive outcome measures based exclusively on abnormal points in microperimetry testing of eyes with intermediate age-related macular degeneration (iAMD). 25 eyes of 25 subjects with iAMD had undergone 2 successive tests of mesopic microperimetry with the Macular Integrity Assessment Microperimeter (MAIA), using a custom grid of 33 points spanning the central 14 degrees of the macula. Each point was defined as abnormal if its threshold sensitivity was lower than 1.65 standard deviations (SD) (5%) or 2 SD (2.5%) than the expected threshold in healthy eyes according to the MAIA internal database. Among the 25 eyes there were 11.8 ± 9 and 8.4 ± 8.2 abnormal points at 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-83716-w