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Retinol-binding protein type 1 expression predicts poor prognosis in head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent malignancy worldwide, with high incidence and poor survival rates. RBP1 is highly expressed in several kinds of cancer and plays a potential prognostic factor. However, the relationship between RBP1 and HNSCC were analyzed bas...
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| Published in: | BMC cancer 2024-10, Vol.24 (1), p.1277-13, Article 1277 |
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| creator | Fu, Ling-Ling Yan, Ming Yu, Xin Shao, Min Gosau, Martin Friedrich, Reinhard E Vollkommer, Tobias Smeets, Ralf Feng, Hong-Chao Xu, Liya |
| description | Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent malignancy worldwide, with high incidence and poor survival rates. RBP1 is highly expressed in several kinds of cancer and plays a potential prognostic factor. However, the relationship between RBP1 and HNSCC were analyzed based on The Cancer Genome Atlas (TCGA) database.
RBP1 expression and clinical information were obtained from the Cancer Genome Atlas (TCGA) database. Tumor tissue and adjacent normal tissue of 6 HNSCC patients were collected to analyze the RBP1 mRNA expression level by quantitative PCR. Cox regression analysis was used to evaluate the prognostic values of RBP1 and clinical data in HNSCC. A nomogram was also established to predict the impact of RBP1 on prognosis based on Cox multivariate results. The methylation level of RBP1 in HNSC and its prognosis were analyzed in UALACN and MethSurv. Finally, the potential biological functions of RBP1 were investigated using gene set enrichment analysis (GSEA) and single sample GSEA (ssGSEA).
The mRNA expression levels of RBP1 were highly expressed in HNSCC tissue. The Cox analyses demonstrate that highly-expressed RBP1 is an independent prognosis marker(P |
| doi_str_mv | 10.1186/s12885-024-12565-3 |
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RBP1 expression and clinical information were obtained from the Cancer Genome Atlas (TCGA) database. Tumor tissue and adjacent normal tissue of 6 HNSCC patients were collected to analyze the RBP1 mRNA expression level by quantitative PCR. Cox regression analysis was used to evaluate the prognostic values of RBP1 and clinical data in HNSCC. A nomogram was also established to predict the impact of RBP1 on prognosis based on Cox multivariate results. The methylation level of RBP1 in HNSC and its prognosis were analyzed in UALACN and MethSurv. Finally, the potential biological functions of RBP1 were investigated using gene set enrichment analysis (GSEA) and single sample GSEA (ssGSEA).
The mRNA expression levels of RBP1 were highly expressed in HNSCC tissue. The Cox analyses demonstrate that highly-expressed RBP1 is an independent prognosis marker(P < 0.05). ROC curve analysis showed that performances of RBP1 (area under the ROC curve: 0.887, sensitivity: 84.1%, specificity: 79.9%). The methylation was increased in HNSCC patients compared with normal subjects(P < 0.05) and was associated with better prognosis at sites cg06208339, cg12298268, cg12497564, cg15288618, cg20532370, cg23448348. Additionally, RBP1 expression is mildly associated with immune cell infiltration and immunological checkpoints.
RBP1 is overexpressed and associated with poor patient prognosis in head and neck squamous cell carcinoma.</description><identifier>ISSN: 1471-2407</identifier><identifier>EISSN: 1471-2407</identifier><identifier>DOI: 10.1186/s12885-024-12565-3</identifier><identifier>PMID: 39407127</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Aged ; Analysis ; B cells ; Bioinformatic analysis ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Cancer ; Cancer therapies ; Care and treatment ; Cell survival ; Demographic aspects ; Diagnosis ; DNA Methylation ; Female ; Gene expression ; Gene Expression Regulation, Neoplastic ; Gene set enrichment analysis ; Genetic aspects ; Genomes ; Genomics ; Head and neck cancer ; Head and neck carcinoma ; Head and Neck Neoplasms - genetics ; Head and Neck Neoplasms - metabolism ; Head and Neck Neoplasms - mortality ; Head and Neck Neoplasms - pathology ; Head and neck squamous cell carcinoma ; Health aspects ; Humans ; Lymphocytes ; Male ; Malignancy ; Mann-Whitney U test ; Medical prognosis ; Metastases ; Metastasis ; Methylation ; Middle Aged ; Nomograms ; Prognosis ; Prognosis biomarker ; Protein binding ; Proteins ; RBP1 ; Retinoids ; Retinol-binding protein ; Retinol-Binding Proteins, Cellular ; Retinol-Binding Proteins, Plasma - genetics ; Retinol-Binding Proteins, Plasma - metabolism ; RNA ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Software ; Squamous cell carcinoma ; Squamous Cell Carcinoma of Head and Neck - genetics ; Squamous Cell Carcinoma of Head and Neck - metabolism ; Squamous Cell Carcinoma of Head and Neck - mortality ; Squamous Cell Carcinoma of Head and Neck - pathology ; Survival analysis ; Tumors ; Vitamin A</subject><ispartof>BMC cancer, 2024-10, Vol.24 (1), p.1277-13, Article 1277</ispartof><rights>2024. The Author(s).</rights><rights>COPYRIGHT 2024 BioMed Central Ltd.</rights><rights>2024. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c510t-f0a16535aa60d6b2ba43fdf5245446ea185b2a1f834cb1fe23b7f07c1911343b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476480/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3126414895?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39407127$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fu, Ling-Ling</creatorcontrib><creatorcontrib>Yan, Ming</creatorcontrib><creatorcontrib>Yu, Xin</creatorcontrib><creatorcontrib>Shao, Min</creatorcontrib><creatorcontrib>Gosau, Martin</creatorcontrib><creatorcontrib>Friedrich, Reinhard E</creatorcontrib><creatorcontrib>Vollkommer, Tobias</creatorcontrib><creatorcontrib>Smeets, Ralf</creatorcontrib><creatorcontrib>Feng, Hong-Chao</creatorcontrib><creatorcontrib>Xu, Liya</creatorcontrib><title>Retinol-binding protein type 1 expression predicts poor prognosis in head and neck squamous cell carcinoma</title><title>BMC cancer</title><addtitle>BMC Cancer</addtitle><description>Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent malignancy worldwide, with high incidence and poor survival rates. RBP1 is highly expressed in several kinds of cancer and plays a potential prognostic factor. However, the relationship between RBP1 and HNSCC were analyzed based on The Cancer Genome Atlas (TCGA) database.
RBP1 expression and clinical information were obtained from the Cancer Genome Atlas (TCGA) database. Tumor tissue and adjacent normal tissue of 6 HNSCC patients were collected to analyze the RBP1 mRNA expression level by quantitative PCR. Cox regression analysis was used to evaluate the prognostic values of RBP1 and clinical data in HNSCC. A nomogram was also established to predict the impact of RBP1 on prognosis based on Cox multivariate results. The methylation level of RBP1 in HNSC and its prognosis were analyzed in UALACN and MethSurv. Finally, the potential biological functions of RBP1 were investigated using gene set enrichment analysis (GSEA) and single sample GSEA (ssGSEA).
The mRNA expression levels of RBP1 were highly expressed in HNSCC tissue. The Cox analyses demonstrate that highly-expressed RBP1 is an independent prognosis marker(P < 0.05). ROC curve analysis showed that performances of RBP1 (area under the ROC curve: 0.887, sensitivity: 84.1%, specificity: 79.9%). The methylation was increased in HNSCC patients compared with normal subjects(P < 0.05) and was associated with better prognosis at sites cg06208339, cg12298268, cg12497564, cg15288618, cg20532370, cg23448348. Additionally, RBP1 expression is mildly associated with immune cell infiltration and immunological checkpoints.
RBP1 is overexpressed and associated with poor patient prognosis in head and neck squamous cell carcinoma.</description><subject>Aged</subject><subject>Analysis</subject><subject>B cells</subject><subject>Bioinformatic analysis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Cell survival</subject><subject>Demographic aspects</subject><subject>Diagnosis</subject><subject>DNA Methylation</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene set enrichment analysis</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Head and neck cancer</subject><subject>Head and neck carcinoma</subject><subject>Head and Neck Neoplasms - genetics</subject><subject>Head and Neck Neoplasms - metabolism</subject><subject>Head and Neck Neoplasms - mortality</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and neck squamous cell carcinoma</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Malignancy</subject><subject>Mann-Whitney U test</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Methylation</subject><subject>Middle Aged</subject><subject>Nomograms</subject><subject>Prognosis</subject><subject>Prognosis biomarker</subject><subject>Protein binding</subject><subject>Proteins</subject><subject>RBP1</subject><subject>Retinoids</subject><subject>Retinol-binding protein</subject><subject>Retinol-Binding Proteins, Cellular</subject><subject>Retinol-Binding Proteins, Plasma - genetics</subject><subject>Retinol-Binding Proteins, Plasma - metabolism</subject><subject>RNA</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Software</subject><subject>Squamous cell carcinoma</subject><subject>Squamous Cell Carcinoma of Head and Neck - genetics</subject><subject>Squamous Cell Carcinoma of Head and Neck - metabolism</subject><subject>Squamous Cell Carcinoma of Head and Neck - mortality</subject><subject>Squamous Cell Carcinoma of Head and Neck - pathology</subject><subject>Survival analysis</subject><subject>Tumors</subject><subject>Vitamin A</subject><issn>1471-2407</issn><issn>1471-2407</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkl1rFDEUhgdRbK3-AS9kQBC9mJqTZGayV1KKHwsFoep1yOc060wyTTLS_nuz3Vp3RXKRcPKcN8mbt6peAjoFYN37BJixtkGYNoDbrm3Io-oYaA8Npqh_vLc-qp6ltEEIeobY0-qIrEoRcH9cbS5Ndj6MjXReOz_UcwzZOF_n29nUUJubOZqUXPBlx2incqrnEOKWG3xILtUFvjJC18Lr2hv1s07Xi5jCkmplxrFWIqpywiSeV0-sGJN5cT-fVD8-ffx-_qW5-Pp5fX520agWUG4sEtC1pBWiQ7qTWApKrLYtpi2lnRHAWokFWEaokmANJrK3qFewAiCUSHJSrXe6OogNn6ObRLzlQTh-Vwhx4CJmp0bDCUirtUFglaTUGsloUTcaVkwSaFXR-rDTmhc5Ga2Mz1GMB6KHO95d8SH84lC87yhDReHtvUIM14tJmU8ubY0R3hSPyhWgRz3FhBT09T_oJizRF68KhTsKlK3av9Qgyguct6EcrLai_IwBphig6wt1-h-qDG0mp4I31pX6QcO7g4bCZHOTB7GkxNffLg_ZN3ts-fwxX6UwLrnEJB2CeAeqGFKKxj44B4hvM8x3GeYlw_wuw3xrw6t9zx9a_oSW_AbDW-rd</recordid><startdate>20241015</startdate><enddate>20241015</enddate><creator>Fu, Ling-Ling</creator><creator>Yan, Ming</creator><creator>Yu, Xin</creator><creator>Shao, Min</creator><creator>Gosau, Martin</creator><creator>Friedrich, Reinhard E</creator><creator>Vollkommer, Tobias</creator><creator>Smeets, Ralf</creator><creator>Feng, Hong-Chao</creator><creator>Xu, Liya</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20241015</creationdate><title>Retinol-binding protein type 1 expression predicts poor prognosis in head and neck squamous cell carcinoma</title><author>Fu, Ling-Ling ; Yan, Ming ; Yu, Xin ; Shao, Min ; Gosau, Martin ; Friedrich, Reinhard E ; Vollkommer, Tobias ; Smeets, Ralf ; Feng, Hong-Chao ; Xu, Liya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-f0a16535aa60d6b2ba43fdf5245446ea185b2a1f834cb1fe23b7f07c1911343b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Analysis</topic><topic>B cells</topic><topic>Bioinformatic analysis</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Cell survival</topic><topic>Demographic aspects</topic><topic>Diagnosis</topic><topic>DNA Methylation</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene set enrichment analysis</topic><topic>Genetic aspects</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Head and neck cancer</topic><topic>Head and neck carcinoma</topic><topic>Head and Neck Neoplasms - genetics</topic><topic>Head and Neck Neoplasms - metabolism</topic><topic>Head and Neck Neoplasms - mortality</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and neck squamous cell carcinoma</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Malignancy</topic><topic>Mann-Whitney U test</topic><topic>Medical prognosis</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Methylation</topic><topic>Middle Aged</topic><topic>Nomograms</topic><topic>Prognosis</topic><topic>Prognosis biomarker</topic><topic>Protein binding</topic><topic>Proteins</topic><topic>RBP1</topic><topic>Retinoids</topic><topic>Retinol-binding protein</topic><topic>Retinol-Binding Proteins, Cellular</topic><topic>Retinol-Binding Proteins, Plasma - genetics</topic><topic>Retinol-Binding Proteins, Plasma - metabolism</topic><topic>RNA</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Software</topic><topic>Squamous cell carcinoma</topic><topic>Squamous Cell Carcinoma of Head and Neck - genetics</topic><topic>Squamous Cell Carcinoma of Head and Neck - metabolism</topic><topic>Squamous Cell Carcinoma of Head and Neck - mortality</topic><topic>Squamous Cell Carcinoma of Head and Neck - pathology</topic><topic>Survival analysis</topic><topic>Tumors</topic><topic>Vitamin A</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fu, Ling-Ling</creatorcontrib><creatorcontrib>Yan, Ming</creatorcontrib><creatorcontrib>Yu, Xin</creatorcontrib><creatorcontrib>Shao, Min</creatorcontrib><creatorcontrib>Gosau, Martin</creatorcontrib><creatorcontrib>Friedrich, Reinhard E</creatorcontrib><creatorcontrib>Vollkommer, Tobias</creatorcontrib><creatorcontrib>Smeets, Ralf</creatorcontrib><creatorcontrib>Feng, Hong-Chao</creatorcontrib><creatorcontrib>Xu, Liya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Science in Context</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>BMC cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fu, Ling-Ling</au><au>Yan, Ming</au><au>Yu, Xin</au><au>Shao, Min</au><au>Gosau, Martin</au><au>Friedrich, Reinhard E</au><au>Vollkommer, Tobias</au><au>Smeets, Ralf</au><au>Feng, Hong-Chao</au><au>Xu, Liya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinol-binding protein type 1 expression predicts poor prognosis in head and neck squamous cell carcinoma</atitle><jtitle>BMC cancer</jtitle><addtitle>BMC Cancer</addtitle><date>2024-10-15</date><risdate>2024</risdate><volume>24</volume><issue>1</issue><spage>1277</spage><epage>13</epage><pages>1277-13</pages><artnum>1277</artnum><issn>1471-2407</issn><eissn>1471-2407</eissn><abstract>Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent malignancy worldwide, with high incidence and poor survival rates. RBP1 is highly expressed in several kinds of cancer and plays a potential prognostic factor. However, the relationship between RBP1 and HNSCC were analyzed based on The Cancer Genome Atlas (TCGA) database.
RBP1 expression and clinical information were obtained from the Cancer Genome Atlas (TCGA) database. Tumor tissue and adjacent normal tissue of 6 HNSCC patients were collected to analyze the RBP1 mRNA expression level by quantitative PCR. Cox regression analysis was used to evaluate the prognostic values of RBP1 and clinical data in HNSCC. A nomogram was also established to predict the impact of RBP1 on prognosis based on Cox multivariate results. The methylation level of RBP1 in HNSC and its prognosis were analyzed in UALACN and MethSurv. Finally, the potential biological functions of RBP1 were investigated using gene set enrichment analysis (GSEA) and single sample GSEA (ssGSEA).
The mRNA expression levels of RBP1 were highly expressed in HNSCC tissue. The Cox analyses demonstrate that highly-expressed RBP1 is an independent prognosis marker(P < 0.05). ROC curve analysis showed that performances of RBP1 (area under the ROC curve: 0.887, sensitivity: 84.1%, specificity: 79.9%). The methylation was increased in HNSCC patients compared with normal subjects(P < 0.05) and was associated with better prognosis at sites cg06208339, cg12298268, cg12497564, cg15288618, cg20532370, cg23448348. Additionally, RBP1 expression is mildly associated with immune cell infiltration and immunological checkpoints.
RBP1 is overexpressed and associated with poor patient prognosis in head and neck squamous cell carcinoma.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>39407127</pmid><doi>10.1186/s12885-024-12565-3</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| subjects | Aged Analysis B cells Bioinformatic analysis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Cancer therapies Care and treatment Cell survival Demographic aspects Diagnosis DNA Methylation Female Gene expression Gene Expression Regulation, Neoplastic Gene set enrichment analysis Genetic aspects Genomes Genomics Head and neck cancer Head and neck carcinoma Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - mortality Head and Neck Neoplasms - pathology Head and neck squamous cell carcinoma Health aspects Humans Lymphocytes Male Malignancy Mann-Whitney U test Medical prognosis Metastases Metastasis Methylation Middle Aged Nomograms Prognosis Prognosis biomarker Protein binding Proteins RBP1 Retinoids Retinol-binding protein Retinol-Binding Proteins, Cellular Retinol-Binding Proteins, Plasma - genetics Retinol-Binding Proteins, Plasma - metabolism RNA RNA, Messenger - genetics RNA, Messenger - metabolism Software Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - genetics Squamous Cell Carcinoma of Head and Neck - metabolism Squamous Cell Carcinoma of Head and Neck - mortality Squamous Cell Carcinoma of Head and Neck - pathology Survival analysis Tumors Vitamin A |
| title | Retinol-binding protein type 1 expression predicts poor prognosis in head and neck squamous cell carcinoma |
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