3D Propolis-Sodium Alginate Scaffolds: Influence on Structural Parameters, Release Mechanisms, Cell Cytotoxicity and Antibacterial Activity

In this study, the main aim was to fabricate propolis (Ps)-containing wound dressing patches using 3D printing technology. Different combinations and structures of propolis (Ps)-incorporated sodium alginate (SA) scaffolds were developed. The morphological studies showed that the porosity of develope...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2020-11, Vol.25 (21), p.5082
Main Authors: Aranci, Kubra, Uzun, Muhammet, Su, Sena, Cesur, Sumeyye, Ulag, Songul, Amin, Al, Guncu, Mehmet Mucahit, Aksu, Burak, Kolayli, Sevgi, Ustundag, Cem Bulent, Silva, Jorge Carvalho, Ficai, Denisa, Ficai, Anton, Gunduz, Oguzhan
Format: Article
Language:English
Subjects:
3-D printers
3D printing
Additive manufacturing
Alginates - chemistry
Alginic acid
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Antibiotics
Antimicrobial agents
Cell Line
Cytotoxicity
Diabetes
E coli
Escherichia coli - growth & development
Fibroblasts - metabolism
Humans
Hydrogels
In vitro methods and tests
Materials Testing
Mechanical properties
Methods
Polymers
Porosity
Printing, Three-Dimensional
Propolis
Propolis - chemistry
Scaffolds
Sodium
Sodium alginate
Software
Staphylococcus aureus - growth & development
tissue scaffold
Tissue Scaffolds - chemistry
Toxicity testing
Ulcers
Weight loss
Wound healing
wound treatment
Wounds
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Summary:In this study, the main aim was to fabricate propolis (Ps)-containing wound dressing patches using 3D printing technology. Different combinations and structures of propolis (Ps)-incorporated sodium alginate (SA) scaffolds were developed. The morphological studies showed that the porosity of developed scaffolds was optimized when 20% ( / ) of Ps was added to the solution. The pore sizes decreased by increasing Ps concentration up to a certain level due to its adhesive properties. The mechanical, swelling-degradation (weight loss) behaviors, and Ps release kinetics were highlighted for the scaffold stability. An antimicrobial assay was employed to test and screen antimicrobial behavior of Ps against and strains. The results show that the Ps-added scaffolds have an excellent antibacterial activity because of Ps compounds. An in vitro cytotoxicity test was also applied on the scaffold by using the extract method on the human dermal fibroblasts (HFFF2) cell line. The 3D-printed SA-Ps scaffolds are very useful structures for wound dressing applications.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25215082