Endothelial Dysfunction in Kidney Transplantation

Kidney transplantation entails a high likelihood of endothelial injury. The endothelium is a target of choice for injury by ischemia-reperfusion, alloantibodies, and autoantibodies. A certain degree of ischemia-reperfusion injury inevitably occurs in the immediate posttransplant setting and can mani...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology 2018-05, Vol.9, p.1130-1130
Main Authors: Cardinal, Héloïse, Dieudé, Mélanie, Hébert, Marie-Josée
Format: Article
Language:English
Subjects:
alloantibodies
apoptosis
autoantibodies
endothelial injury
Immunology
kidney transplantation
necroptosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Kidney transplantation entails a high likelihood of endothelial injury. The endothelium is a target of choice for injury by ischemia-reperfusion, alloantibodies, and autoantibodies. A certain degree of ischemia-reperfusion injury inevitably occurs in the immediate posttransplant setting and can manifest as delayed graft function. Acute rejection episodes, whether T-cell or antibody-mediated, can involve the graft micro- and macrovasculature, leading to endothelial injury and adverse long-term consequences on graft function and survival. In turn, caspase-3 activation in injured and dying endothelial cells favors the release of extracellular vesicles (apoptotic bodies and apoptotic exosome-like vesicles) that further enhance autoantibody production, complement deposition, and microvascular rarefaction. In this review, we present the evidence for endothelial injury, its causes and long-term consequences on graft outcomes in the field of kidney transplantation.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2018.01130