Breast cancer in women with previous gestational diabetes: a nationwide register-based cohort study

Gestational diabetes mellitus (GDM) is a common pregnancy complication characterized by insulin resistance. A link has been suggested between insulin resistance and breast cancer, which is the most common cancer in women. Hence, women with previous GDM may be at increased risk of developing breast c...

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Bibliographic Details
Published in:Breast cancer research : BCR 2024-11, Vol.26 (1), p.150-10, Article 150
Main Authors: Christensen, Maria Hornstrup, Vinter, Christina Anne, Olesen, Thomas Bastholm, Petersen, Maria Houborg, Nohr, Ellen Aagaard, Rubin, Katrine Hass, Andersen, Marianne Skovsager, Jensen, Dorte Moeller
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis
Breast cancer
Breast Neoplasms - epidemiology
Cancer
Cohort Studies
Denmark - epidemiology
Development and progression
Diabetes in pregnancy
Diabetes, Gestational - epidemiology
Diagnosis
Female
Gestational diabetes
Humans
Incidence
Insulin
Insulin Resistance
Menopause
Middle Aged
Oncology, Experimental
Postmenopausal breast cancer
Postmenopausal women
Pregnancy
Pregnant women
Premenopausal breast cancer
Register-based cohort study
Registries
Risk Factors
Type 2 diabetes
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Summary:Gestational diabetes mellitus (GDM) is a common pregnancy complication characterized by insulin resistance. A link has been suggested between insulin resistance and breast cancer, which is the most common cancer in women. Hence, women with previous GDM may be at increased risk of developing breast cancer, yet, the existing evidence is conflicting. This study explored the association between GDM and incident breast cancer, including age at cancer diagnosis. Additionally, we investigated the potential impact of severity of insulin resistance during pregnancy and of subsequent diabetes development on the breast cancer risk. We conducted a nationwide, register-based cohort study including all women giving birth in Denmark from 1997 to 2018. We defined GDM and breast cancer based on ICD-10 codes. Premenopausal and postmenopausal breast cancer was pragmatically defined as age at outcome 
ISSN:1465-542X
1465-5411
1465-542X
DOI:10.1186/s13058-024-01908-4