An investigation of antioxidative and anti-inflammatory effects of Taraxacum coreanum (white dandelion) in lactating Holstein dairy cows

• Published in: Journal of advanced veterinary and animal research 2024-06, Vol.11 (2), p.330-338
• Main Authors: Kim, Sung Jae, Jo, Young Jun, Jeong, Sang-Hee, Kim, Yo-Han, Hee Han, Jeong
• Format: Article
• Language: English
• Subjects: Additives; antioxidant; dairy cow; proinflammatory cytokine; somatic cell count; taraxacum coreanum; Antioxidants; Bioassays; Blood; Cattle; Chemokines; Cow's milk; Cytokines; Dairy cattle; Enzymes; Feed additives; Feeds; Food additives; Glutathione; Glutathione peroxidase; Hematology; Herbal medicine; Immune response; Immune system; Interleukin 8; Laboratory animals; Leukocytes; Medicinal herbs; Medicinal plants; Milk production; Mixtures; Original; Peripheral blood; Peroxidase; Superoxide dismutase; Taraxacum coreanum; Total mixed rations; Toxicity; Tumor necrosis factor-TNF; Tumor necrosis factor-α
• ISSN: 2311-7710; 2311-7710
• DOI: 10.5455/javar.2024.k781

The aim of this investigation was to examine the impact of (known as dandelion) (TC) and TC mixtures with milk thistle (MT) or (AO) as feed additives on the immune response, milk quality, and milk production in Holstein cows over 6 weeks of administration. Thirty-two healthy Holstein dairy cows were provided 30 kg of total mixed ration (TMR) with no TC, 90 gm TC, 54 gm TC + 36 gm MT, or 54 gm TC + 36 gm AO 40% groups. The feed additives were supplied daily in two equal portions (per 45 gm) by topdressing the TMR for 6 weeks. Milk and blood samples were collected weekly. In the TC-treated cows (TC, TC + MT, and TC + AO groups), significantly lower peripheral blood white blood cell (WBC) counts at 6 weeks and milk somatic cell counts (SCCs) at 4-6 weeks of administration were observed. Concentrations of serum superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) were notably elevated in cows treated with TC for 4-6 weeks, while levels of proinflammatory cytokines concentrations of tumor necrosis factor-alpha (TNF-α) and chemokine (IL-8) were significantly reduced in TC-treated cows after 3-6 weeks of administration. These results suggested that TC or a TC mixture with other medicinal herbs supplementations enhanced the serum antioxidative activities and, consequently, might suppress the adverse immune response due to lower serum TNF-α and IL-8 release supported by lower WBC and SCC counts.