Hepatitis B virus infection profile in hemodialysis patients in Central Brazil: prevalence, risk factors, and genotypes

Hemodialysis patients are at high risk for hepatitis B virus (HBV) infection. A survey was conducted in the hemodialysis population of the state of Goiás, Central Brazil, aiming to assess the prevalence of HBV infection, to analyse associated risk factors, and also to investigate HBV genotypes distr...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz 2006-09, Vol.101 (6), p.689-692
Main Authors: Ferreira, Renata C, Teles, Sheila A, Dias, Márcia A, Tavares, Viviane R, Silva, Simonne A, Gomes, Selma A, Yoshida, Clara F T, Martins, Regina M B
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers - blood
Brazil - epidemiology
Central Brazil
Child
Child, Preschool
DNA, Viral - analysis
Enzyme-Linked Immunosorbent Assay
Female
Genotype
hemodialysis
Hepatitis B - diagnosis
Hepatitis B - epidemiology
Hepatitis B - etiology
Hepatitis B Antibodies - blood
Hepatitis B Surface Antigens - blood
hepatitis B virus
Hepatitis B virus - genetics
hepatitis B virus - hemodialysis - Central Brazil
Hepatitis B virus - immunology
Humans
Male
Middle Aged
Multivariate Analysis
PARASITOLOGY
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Prevalence
Renal Dialysis - adverse effects
Risk Factors
TROPICAL MEDICINE
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Summary:Hemodialysis patients are at high risk for hepatitis B virus (HBV) infection. A survey was conducted in the hemodialysis population of the state of Goiás, Central Brazil, aiming to assess the prevalence of HBV infection, to analyse associated risk factors, and also to investigate HBV genotypes distribution. A total of 1095 patients were interviewed in 15 dialysis units. Serum samples were screened for HBV serological markers by enzyme-linked immunosorbent assay. Hepatitis B surface antigen (HBsAg) positive samples were tested for HBV DNA by polymerase chain reaction and genotyped by restriction fragment length polymorphism. Global HBV infection prevalence was 29.8% (95% CI: 27.1-32.5). Multivariate analysis of risk factors showed that male gender, length of time on hemodialysis, and blood transfusion before 1993 were associated with HBV positivity. HBV DNA was detected in 65.4% (17/26) of the HBsAg-positive samples. Thirteen of 17 HBV DNA positive samples were genotyped. Genotype D (61.5%) was predominant, followed by A (30.8%), while genotype F was detected in only one (7.7%) sample.
ISSN:1678-8060
0074-0276
0074-0276
1678-8060
DOI:10.1590/S0074-02762006000600019