Chronic mild prenatal stress exacerbates the allergen-induced airway inflammation in rats

THE effects of chronic mild prenatal stress on leukocyte infiltration into the airways was investigated in rat offspring. The chronic prenatal stress consisted of transitory and variable changes in the rat's living conditions. Offspring at adult age were actively sensitized (day 0) and intratra...

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Bibliographic Details
Published in:Mediators of Inflammation 1999-01, Vol.1999 (2), p.119-122
Main Authors: Nogueira, P J, Ferreira, H H, Antunes, E, Teixeira, N A
Format: Article
Language:English
Subjects:
Allergens
Animals
Bronchial Hyperreactivity - etiology
Bronchial Hyperreactivity - physiopathology
Eosinophils - physiology
Female
Food Deprivation
Housing, Animal
Inflammation - physiopathology
Leukocyte Count
Ovalbumin
Pregnancy
Pregnancy Complications - psychology
Prenatal Exposure Delayed Effects
Prenatal stress
Eosinophils
Asthma
Development
Lungs
Rats
Rats, Wistar
Stress, Psychological
Water Deprivation
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Summary:THE effects of chronic mild prenatal stress on leukocyte infiltration into the airways was investigated in rat offspring. The chronic prenatal stress consisted of transitory and variable changes in the rat's living conditions. Offspring at adult age were actively sensitized (day 0) and intratracheally challenged (day 14) with ovalbumin. Bronchoalveolar lavage was performed in the offspring at 48 h after intratracheal challenge with ovalbumin. A significant increase in total leukocyte infiltration was observed in the nonstressed offspring group and this was associated with a marked recruitment of eosinophils without a significant effect on the influx of neutrophils and mononuclear cells. In the prenatal stressed offspring, the counts of both total leukocyte and eosinophils, as well as mononuclear cells, was increased by 50% compared to the non-stressed offspring. We provide here the first experimental evidence that chronic mild unpredictable prenatal stress produces a marked increase in the allergen-induced airway inflammation in the rat offspring.
ISSN:0962-9351
1466-1861
DOI:10.1080/09629359990621