Loading…

Utility of the Novel MediPost Mobile Posturography Device in the Assessment of Patients with a Unilateral Vestibular Disorder

Balance disorders are a growing problem worldwide. Thus, there is an increasing need to provide an inexpensive and feasible alternative to standard posturographic platforms (SP) used for the assessment of balance and to provide a possible solution for telemonitoring of patients. A novel mobile postu...

Full description

Saved in:
Bibliographic Details
Published in:Sensors (Basel, Switzerland) Switzerland), 2022-03, Vol.22 (6), p.2208
Main Authors: Rosiak, Oskar, Gawronska, Anna, Janc, Magdalena, Marciniak, Pawel, Kotas, Rafal, Zamyslowska-Szmytke, Ewa, Jozefowicz-Korczynska, Magdalena
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c469t-4e1e67fc535b0c96efd2c35af54afe4faceaabe43afb15479813bb956c3d03493
cites cdi_FETCH-LOGICAL-c469t-4e1e67fc535b0c96efd2c35af54afe4faceaabe43afb15479813bb956c3d03493
container_end_page
container_issue 6
container_start_page 2208
container_title Sensors (Basel, Switzerland)
container_volume 22
creator Rosiak, Oskar
Gawronska, Anna
Janc, Magdalena
Marciniak, Pawel
Kotas, Rafal
Zamyslowska-Szmytke, Ewa
Jozefowicz-Korczynska, Magdalena
description Balance disorders are a growing problem worldwide. Thus, there is an increasing need to provide an inexpensive and feasible alternative to standard posturographic platforms (SP) used for the assessment of balance and to provide a possible solution for telemonitoring of patients. A novel mobile posturography (MP) MediPost device was developed to address these issues. This prospective study used a Modified Clinical Test of Sensory Interaction on Balance to evaluate healthy individuals and patients with a unilateral vestibular disorder through SP and MP simultaneously. The control group included 65 healthy volunteers, while the study group included 38 patients diagnosed with a unilateral vestibular deficit. The angular velocity values obtained from both methods were compared by intraclass correlation coefficients (ICC) and Bland−Altman plot analysis. Diagnostic capabilities were measured in terms of sensitivity and specificity. The ICC between the two methods for conditions 2−4 was indicative of excellent reliability, with the ICC > 0.9 (p < 0.001), except for Condition 1 (standing stance, eyes open) ICC = 0.685, p < 0.001, which is indicative of moderate reliability. ROC curve analysis of angular velocity for condition 4 represents the most accurate differentiating factor with AUC values of 0.939 for SP and 0.953 for MP. This condition also reported the highest sensitivity, specificity, PPV, and NPV values with 86.4%, 87.7%, 80%, and 90.5% for SP, and 92.1%, 84.6%, 77.8%, and 94.8% for MP, respectively. The newly developed MediPost device has high sensitivity and specificity in distinguishing between healthy individuals and patients with a unilateral vestibular deficit.
doi_str_mv 10.3390/s22062208
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_31f8ecb9f3bd42ec945a3190ffe618ed</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_31f8ecb9f3bd42ec945a3190ffe618ed</doaj_id><sourcerecordid>2642630406</sourcerecordid><originalsourceid>FETCH-LOGICAL-c469t-4e1e67fc535b0c96efd2c35af54afe4faceaabe43afb15479813bb956c3d03493</originalsourceid><addsrcrecordid>eNpVkc1uGyEUhUdVqyZNu-gLVEhdZeEW5gIeNpWipD-RkjaLulsEzMXGGhsXGFde9N2L49RKFogDnPvB5TTNW0Y_ACj6MbctlXV0z5pTxls-6eri-SN90rzKeUlpCwDdy-YEBICEqTpt_s5KGELZkehJWSD5Hrc4kFvsw13MhdxGGwYkez2mOE9ms9iRK9wGhySs7ysucsacV7gue8adKaHKTP6EsiCGzNZhMAWTGcgvzCXYcTCJXIUcU4_pdfPCmyHjm4f5rJl9-fzz8tvk5sfX68uLm4njUpUJR4Zy6p0AYalTEn3fOhDGC248cm8cGmORg_GWCT5VHQNrlZAOegpcwVlzfeD20Sz1JoWVSTsdTdD3GzHNtUkluAE1MN-hs8qD7XmLTnFhgCnqPUrWYV9Znw6szWhX2Lvabe3uCfTpyTos9DxudacEKCYq4P0DIMXfY_0UvYxjWtf-dSt5K4FyKqvr_OByKeac0B9vYFTvU9fH1Kv33eMnHZ3_Y4Z_VwSq1Q</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2642630406</pqid></control><display><type>article</type><title>Utility of the Novel MediPost Mobile Posturography Device in the Assessment of Patients with a Unilateral Vestibular Disorder</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Rosiak, Oskar ; Gawronska, Anna ; Janc, Magdalena ; Marciniak, Pawel ; Kotas, Rafal ; Zamyslowska-Szmytke, Ewa ; Jozefowicz-Korczynska, Magdalena</creator><creatorcontrib>Rosiak, Oskar ; Gawronska, Anna ; Janc, Magdalena ; Marciniak, Pawel ; Kotas, Rafal ; Zamyslowska-Szmytke, Ewa ; Jozefowicz-Korczynska, Magdalena</creatorcontrib><description>Balance disorders are a growing problem worldwide. Thus, there is an increasing need to provide an inexpensive and feasible alternative to standard posturographic platforms (SP) used for the assessment of balance and to provide a possible solution for telemonitoring of patients. A novel mobile posturography (MP) MediPost device was developed to address these issues. This prospective study used a Modified Clinical Test of Sensory Interaction on Balance to evaluate healthy individuals and patients with a unilateral vestibular disorder through SP and MP simultaneously. The control group included 65 healthy volunteers, while the study group included 38 patients diagnosed with a unilateral vestibular deficit. The angular velocity values obtained from both methods were compared by intraclass correlation coefficients (ICC) and Bland−Altman plot analysis. Diagnostic capabilities were measured in terms of sensitivity and specificity. The ICC between the two methods for conditions 2−4 was indicative of excellent reliability, with the ICC &gt; 0.9 (p &lt; 0.001), except for Condition 1 (standing stance, eyes open) ICC = 0.685, p &lt; 0.001, which is indicative of moderate reliability. ROC curve analysis of angular velocity for condition 4 represents the most accurate differentiating factor with AUC values of 0.939 for SP and 0.953 for MP. This condition also reported the highest sensitivity, specificity, PPV, and NPV values with 86.4%, 87.7%, 80%, and 90.5% for SP, and 92.1%, 84.6%, 77.8%, and 94.8% for MP, respectively. The newly developed MediPost device has high sensitivity and specificity in distinguishing between healthy individuals and patients with a unilateral vestibular deficit.</description><identifier>ISSN: 1424-8220</identifier><identifier>EISSN: 1424-8220</identifier><identifier>DOI: 10.3390/s22062208</identifier><identifier>PMID: 35336379</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Angular velocity ; Balance ; balance disorders ; Bland–Altmann ; Body mass index ; body-worn sensors ; Communication ; Correlation coefficients ; Humans ; intraclass correlation coefficients ; mobile posturography ; Patients ; Physical Therapy Modalities ; Postural Balance ; Posture ; Prospective Studies ; R&amp;D ; Rehabilitation ; Reliability analysis ; Reproducibility of Results ; Research &amp; development ; Vertigo ; Vestibular Diseases - diagnosis</subject><ispartof>Sensors (Basel, Switzerland), 2022-03, Vol.22 (6), p.2208</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-4e1e67fc535b0c96efd2c35af54afe4faceaabe43afb15479813bb956c3d03493</citedby><cites>FETCH-LOGICAL-c469t-4e1e67fc535b0c96efd2c35af54afe4faceaabe43afb15479813bb956c3d03493</cites><orcidid>0000-0002-5326-4777 ; 0000-0001-6400-0104 ; 0000-0003-4527-6513 ; 0000-0003-0776-9173</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2642630406/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2642630406?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,44569,53769,53771,74872</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35336379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosiak, Oskar</creatorcontrib><creatorcontrib>Gawronska, Anna</creatorcontrib><creatorcontrib>Janc, Magdalena</creatorcontrib><creatorcontrib>Marciniak, Pawel</creatorcontrib><creatorcontrib>Kotas, Rafal</creatorcontrib><creatorcontrib>Zamyslowska-Szmytke, Ewa</creatorcontrib><creatorcontrib>Jozefowicz-Korczynska, Magdalena</creatorcontrib><title>Utility of the Novel MediPost Mobile Posturography Device in the Assessment of Patients with a Unilateral Vestibular Disorder</title><title>Sensors (Basel, Switzerland)</title><addtitle>Sensors (Basel)</addtitle><description>Balance disorders are a growing problem worldwide. Thus, there is an increasing need to provide an inexpensive and feasible alternative to standard posturographic platforms (SP) used for the assessment of balance and to provide a possible solution for telemonitoring of patients. A novel mobile posturography (MP) MediPost device was developed to address these issues. This prospective study used a Modified Clinical Test of Sensory Interaction on Balance to evaluate healthy individuals and patients with a unilateral vestibular disorder through SP and MP simultaneously. The control group included 65 healthy volunteers, while the study group included 38 patients diagnosed with a unilateral vestibular deficit. The angular velocity values obtained from both methods were compared by intraclass correlation coefficients (ICC) and Bland−Altman plot analysis. Diagnostic capabilities were measured in terms of sensitivity and specificity. The ICC between the two methods for conditions 2−4 was indicative of excellent reliability, with the ICC &gt; 0.9 (p &lt; 0.001), except for Condition 1 (standing stance, eyes open) ICC = 0.685, p &lt; 0.001, which is indicative of moderate reliability. ROC curve analysis of angular velocity for condition 4 represents the most accurate differentiating factor with AUC values of 0.939 for SP and 0.953 for MP. This condition also reported the highest sensitivity, specificity, PPV, and NPV values with 86.4%, 87.7%, 80%, and 90.5% for SP, and 92.1%, 84.6%, 77.8%, and 94.8% for MP, respectively. The newly developed MediPost device has high sensitivity and specificity in distinguishing between healthy individuals and patients with a unilateral vestibular deficit.</description><subject>Angular velocity</subject><subject>Balance</subject><subject>balance disorders</subject><subject>Bland–Altmann</subject><subject>Body mass index</subject><subject>body-worn sensors</subject><subject>Communication</subject><subject>Correlation coefficients</subject><subject>Humans</subject><subject>intraclass correlation coefficients</subject><subject>mobile posturography</subject><subject>Patients</subject><subject>Physical Therapy Modalities</subject><subject>Postural Balance</subject><subject>Posture</subject><subject>Prospective Studies</subject><subject>R&amp;D</subject><subject>Rehabilitation</subject><subject>Reliability analysis</subject><subject>Reproducibility of Results</subject><subject>Research &amp; development</subject><subject>Vertigo</subject><subject>Vestibular Diseases - diagnosis</subject><issn>1424-8220</issn><issn>1424-8220</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpVkc1uGyEUhUdVqyZNu-gLVEhdZeEW5gIeNpWipD-RkjaLulsEzMXGGhsXGFde9N2L49RKFogDnPvB5TTNW0Y_ACj6MbctlXV0z5pTxls-6eri-SN90rzKeUlpCwDdy-YEBICEqTpt_s5KGELZkehJWSD5Hrc4kFvsw13MhdxGGwYkez2mOE9ms9iRK9wGhySs7ysucsacV7gue8adKaHKTP6EsiCGzNZhMAWTGcgvzCXYcTCJXIUcU4_pdfPCmyHjm4f5rJl9-fzz8tvk5sfX68uLm4njUpUJR4Zy6p0AYalTEn3fOhDGC248cm8cGmORg_GWCT5VHQNrlZAOegpcwVlzfeD20Sz1JoWVSTsdTdD3GzHNtUkluAE1MN-hs8qD7XmLTnFhgCnqPUrWYV9Znw6szWhX2Lvabe3uCfTpyTos9DxudacEKCYq4P0DIMXfY_0UvYxjWtf-dSt5K4FyKqvr_OByKeac0B9vYFTvU9fH1Kv33eMnHZ3_Y4Z_VwSq1Q</recordid><startdate>20220312</startdate><enddate>20220312</enddate><creator>Rosiak, Oskar</creator><creator>Gawronska, Anna</creator><creator>Janc, Magdalena</creator><creator>Marciniak, Pawel</creator><creator>Kotas, Rafal</creator><creator>Zamyslowska-Szmytke, Ewa</creator><creator>Jozefowicz-Korczynska, Magdalena</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-5326-4777</orcidid><orcidid>https://orcid.org/0000-0001-6400-0104</orcidid><orcidid>https://orcid.org/0000-0003-4527-6513</orcidid><orcidid>https://orcid.org/0000-0003-0776-9173</orcidid></search><sort><creationdate>20220312</creationdate><title>Utility of the Novel MediPost Mobile Posturography Device in the Assessment of Patients with a Unilateral Vestibular Disorder</title><author>Rosiak, Oskar ; Gawronska, Anna ; Janc, Magdalena ; Marciniak, Pawel ; Kotas, Rafal ; Zamyslowska-Szmytke, Ewa ; Jozefowicz-Korczynska, Magdalena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-4e1e67fc535b0c96efd2c35af54afe4faceaabe43afb15479813bb956c3d03493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Angular velocity</topic><topic>Balance</topic><topic>balance disorders</topic><topic>Bland–Altmann</topic><topic>Body mass index</topic><topic>body-worn sensors</topic><topic>Communication</topic><topic>Correlation coefficients</topic><topic>Humans</topic><topic>intraclass correlation coefficients</topic><topic>mobile posturography</topic><topic>Patients</topic><topic>Physical Therapy Modalities</topic><topic>Postural Balance</topic><topic>Posture</topic><topic>Prospective Studies</topic><topic>R&amp;D</topic><topic>Rehabilitation</topic><topic>Reliability analysis</topic><topic>Reproducibility of Results</topic><topic>Research &amp; development</topic><topic>Vertigo</topic><topic>Vestibular Diseases - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosiak, Oskar</creatorcontrib><creatorcontrib>Gawronska, Anna</creatorcontrib><creatorcontrib>Janc, Magdalena</creatorcontrib><creatorcontrib>Marciniak, Pawel</creatorcontrib><creatorcontrib>Kotas, Rafal</creatorcontrib><creatorcontrib>Zamyslowska-Szmytke, Ewa</creatorcontrib><creatorcontrib>Jozefowicz-Korczynska, Magdalena</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Sensors (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosiak, Oskar</au><au>Gawronska, Anna</au><au>Janc, Magdalena</au><au>Marciniak, Pawel</au><au>Kotas, Rafal</au><au>Zamyslowska-Szmytke, Ewa</au><au>Jozefowicz-Korczynska, Magdalena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Utility of the Novel MediPost Mobile Posturography Device in the Assessment of Patients with a Unilateral Vestibular Disorder</atitle><jtitle>Sensors (Basel, Switzerland)</jtitle><addtitle>Sensors (Basel)</addtitle><date>2022-03-12</date><risdate>2022</risdate><volume>22</volume><issue>6</issue><spage>2208</spage><pages>2208-</pages><issn>1424-8220</issn><eissn>1424-8220</eissn><abstract>Balance disorders are a growing problem worldwide. Thus, there is an increasing need to provide an inexpensive and feasible alternative to standard posturographic platforms (SP) used for the assessment of balance and to provide a possible solution for telemonitoring of patients. A novel mobile posturography (MP) MediPost device was developed to address these issues. This prospective study used a Modified Clinical Test of Sensory Interaction on Balance to evaluate healthy individuals and patients with a unilateral vestibular disorder through SP and MP simultaneously. The control group included 65 healthy volunteers, while the study group included 38 patients diagnosed with a unilateral vestibular deficit. The angular velocity values obtained from both methods were compared by intraclass correlation coefficients (ICC) and Bland−Altman plot analysis. Diagnostic capabilities were measured in terms of sensitivity and specificity. The ICC between the two methods for conditions 2−4 was indicative of excellent reliability, with the ICC &gt; 0.9 (p &lt; 0.001), except for Condition 1 (standing stance, eyes open) ICC = 0.685, p &lt; 0.001, which is indicative of moderate reliability. ROC curve analysis of angular velocity for condition 4 represents the most accurate differentiating factor with AUC values of 0.939 for SP and 0.953 for MP. This condition also reported the highest sensitivity, specificity, PPV, and NPV values with 86.4%, 87.7%, 80%, and 90.5% for SP, and 92.1%, 84.6%, 77.8%, and 94.8% for MP, respectively. The newly developed MediPost device has high sensitivity and specificity in distinguishing between healthy individuals and patients with a unilateral vestibular deficit.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35336379</pmid><doi>10.3390/s22062208</doi><orcidid>https://orcid.org/0000-0002-5326-4777</orcidid><orcidid>https://orcid.org/0000-0001-6400-0104</orcidid><orcidid>https://orcid.org/0000-0003-4527-6513</orcidid><orcidid>https://orcid.org/0000-0003-0776-9173</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1424-8220
ispartof Sensors (Basel, Switzerland), 2022-03, Vol.22 (6), p.2208
issn 1424-8220
1424-8220
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_31f8ecb9f3bd42ec945a3190ffe618ed
source Publicly Available Content Database; PubMed Central
subjects Angular velocity
Balance
balance disorders
Bland–Altmann
Body mass index
body-worn sensors
Communication
Correlation coefficients
Humans
intraclass correlation coefficients
mobile posturography
Patients
Physical Therapy Modalities
Postural Balance
Posture
Prospective Studies
R&D
Rehabilitation
Reliability analysis
Reproducibility of Results
Research & development
Vertigo
Vestibular Diseases - diagnosis
title Utility of the Novel MediPost Mobile Posturography Device in the Assessment of Patients with a Unilateral Vestibular Disorder
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T20%3A36%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Utility%20of%20the%20Novel%20MediPost%20Mobile%20Posturography%20Device%20in%20the%20Assessment%20of%20Patients%20with%20a%20Unilateral%20Vestibular%20Disorder&rft.jtitle=Sensors%20(Basel,%20Switzerland)&rft.au=Rosiak,%20Oskar&rft.date=2022-03-12&rft.volume=22&rft.issue=6&rft.spage=2208&rft.pages=2208-&rft.issn=1424-8220&rft.eissn=1424-8220&rft_id=info:doi/10.3390/s22062208&rft_dat=%3Cproquest_doaj_%3E2642630406%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c469t-4e1e67fc535b0c96efd2c35af54afe4faceaabe43afb15479813bb956c3d03493%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2642630406&rft_id=info:pmid/35336379&rfr_iscdi=true