Individualized treatment for allergic rhinitis based on key nasal clinical manifestations combined with histamine and leukotriene D4 levels

The types of allergic rhinitis are roughly classified based on the causative antigens, disease types, predilection time, and symptom severity. To examine the clinical typing and individualized treatment approach for allergic rhinitis and to determine the optimal treatment method for this disease usi...

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Bibliographic Details
Published in:Brazilian journal of otorhinolaryngology 2020-01, Vol.86 (1), p.63-73
Main Authors: Shen, Congxiang, Chen, Fang, Wang, Huigang, Zhang, Xinyu, Li, Guanxue, Wen, Zhong
Format: Article
Language:English
Subjects:
Acetates - therapeutic use
Adolescent
Adult
Aged
Allergic rhinitis
Anti-Allergic Agents - therapeutic use
Clinical typing
Drug Therapy, Combination - methods
Female
Histamina
Histamine
Histamine - blood
Humans
Individualized treatment
Leucotrienos
Leukotriene D4 - blood
Leukotrienes
Loratadine - therapeutic use
Male
Middle Aged
Mometasone Furoate - therapeutic use
Nasal Mucosa
Nasal Obstruction - drug therapy
Original
OTORHINOLARYNGOLOGY
Precision Medicine - methods
Quinolines - therapeutic use
Receptors, Histamine H1 - genetics
Receptors, Leukotriene - genetics
Rhinitis, Allergic - blood
Rhinitis, Allergic - diagnosis
Rhinitis, Allergic - drug therapy
Rinite alérgica
RNA, Messenger - genetics
Sneezing
Tipificação clínica
Tratamento individualizado
Treatment Outcome
Young Adult
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Summary:The types of allergic rhinitis are roughly classified based on the causative antigens, disease types, predilection time, and symptom severity. To examine the clinical typing and individualized treatment approach for allergic rhinitis and to determine the optimal treatment method for this disease using various drug combination therapies. A total of 108 participants with allergic rhinitis were divided into three groups based on symptoms. Subsequently, each group was further categorized into four subgroups based on the medications received. The efficacy of the treatments was evaluated using the visual analog scale VAS scores of the total and individual nasal symptoms, decline index of the symptom score, histamine and leukotriene levels, and mRNA and protein expression levels of histamine 1 and cysteinyl leukotriene 1 receptors. Loratadine+mometasone furoate and loratadine+mometasone furoate+montelukast significantly improved the sneezing symptom and reduced the histamine levels compared with the other combination therapies (p
ISSN:1808-8694
1808-8686
1808-8686
DOI:10.1016/j.bjorl.2018.09.007