Double Trouble: How Microbiome Dysbiosis and Mitochondrial Dysfunction Drive Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are closely related liver conditions that have become more prevalent globally. This review examines the intricate interplay between microbiome dysbiosis and mitochondrial dysfunction in the development of NAFLD and NA...

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Bibliographic Details
Published in:Biomedicines 2024-02, Vol.12 (3), p.550
Main Authors: Bahitham, Wesam, Alghamdi, Siraj, Omer, Ibrahim, Alsudais, Ali, Hakeem, Ilana, Alghamdi, Arwa, Abualnaja, Reema, Sanai, Faisal M, Rosado, Alexandre S, Sergi, Consolato M
Format: Article
Language:English
Subjects:
Alcohol
Biopsy
Cholangitis
Communication
Cytokines
Development and progression
Dysbacteriosis
Fatty liver
fibrosis
Glucose
Health aspects
Hepatitis
Homeostasis
Inflammation
Insulin resistance
Lipids
liver
Liver cancer
Liver cirrhosis
Liver diseases
Medical innovations
Metabolic syndrome
Metabolites
Microbiomes
Microbiota
Mitochondria
Mortality
NAFLD
NASH
Pathogenesis
Peptides
Permeability
Physiology
Review
steatohepatitis
Steatosis
Toxins
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Summary:Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are closely related liver conditions that have become more prevalent globally. This review examines the intricate interplay between microbiome dysbiosis and mitochondrial dysfunction in the development of NAFLD and NASH. The combination of these two factors creates a synergistic situation referred to as "double trouble", which promotes the accumulation of lipids in the liver and the subsequent progression from simple steatosis (NAFLD) to inflammation (NASH). Microbiome dysbiosis, characterized by changes in the composition of gut microbes and increased intestinal permeability, contributes to the movement of bacterial products into the liver. It triggers metabolic disturbances and has anti-inflammatory effects. Understanding the complex relationship between microbiome dysbiosis and mitochondrial dysfunction in the development of NAFLD and NASH is crucial for advancing innovative therapeutic approaches that target these underlying mechanisms.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines12030550