Predicting Cardiovascular Stent Complications Using Self‐Reporting Biosensors for Noninvasive Detection of Disease

Self‐reporting implantable medical devices are the future of cardiovascular healthcare. Cardiovascular complications such as blocked arteries that lead to the majority of heart attacks and strokes are frequently treated with inert metal stents that reopen affected vessels. Stents frequently re‐block...

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Bibliographic Details
Published in:Advanced science 2022-05, Vol.9 (15), p.e2105285-n/a
Main Authors: Hoare, Daniel, Tsiamis, Andreas, Marland, Jamie R. K., Czyzewski, Jakub, Kirimi, Mahmut T., Holsgrove, Michael, Russell, Ewan, Neale, Steven L., Mirzai, Nosrat, Mitra, Srinjoy, Mercer, John R.
Format: Article
Language:English
Subjects:
Apoptosis
Biosensing Techniques
blood clot
Cardiovascular disease
Catheters
Cell division
Coronary Restenosis - etiology
Coronary Restenosis - metabolism
Coronary Restenosis - therapy
Electrodes
Glass substrates
Humans
Medical equipment
Myocardial Infarction - complications
Plaque, Atherosclerotic - complications
restenosis
Sensors
Smooth muscle
Spectrum analysis
stent
Stents
Stents - adverse effects
Thrombosis
Veins & arteries
wireless impedance sensor
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Summary:Self‐reporting implantable medical devices are the future of cardiovascular healthcare. Cardiovascular complications such as blocked arteries that lead to the majority of heart attacks and strokes are frequently treated with inert metal stents that reopen affected vessels. Stents frequently re‐block after deployment due to a wound response called in‐stent restenosis (ISR). Herein, an implantable miniaturized sensor and telemetry system are developed that can detect this process, discern the different cell types associated with ISR, distinguish sub plaque components as demonstrated with ex vivo samples, and differentiate blood from blood clot, all on a silicon substrate making it suitable for integration onto a vascular stent. This work shows that microfabricated sensors can provide clinically relevant information in settings closer to physiological conditions than previous work with cultured cells. An implantable miniaturized sensor and telemetry system is developed that can detect and discern different cell types associated with in stent restenosis, distinguish sub plaque components, and differentiate blood from blood clot. This work shows that microfabricated sensors can provide clinically relevant information in settings closer to physiological conditions than previous work with cultured cells.
ISSN:2198-3844
2198-3844
DOI:10.1002/advs.202105285